RT info:eu-repo/semantics/article
T1 Systematic analysis of FASTK gene family alterations in cancer
A1 Magraner Pardo, Lorena
A1 Gobelli, Dino Joaquin
A1 Fuente García, Miguel Ángel de la
A1 Pons, Tirso
A1 Simarro Grande, María
K1 Medicina
K1 Cancer Research
K1 Oncología
K1 Mitochondria
K1 FASTK
K1 Cancer
K1 Genetic alterations
K1 Mitocondrias
K1 Cáncer
K1 Alteraciones genéticas
K1 3207.13 Oncología
AB The FASTK family of proteins have been recently reported to play a key role in the post-transcriptional regulation of mitochondrial gene expression, including mRNA stability and translation. Accumulated studies have provided evidence that the expression of some FASTK genes is altered in certain types of cancer, in agreement with the central role of mitochondria in cancer development. Here, we obtained a pan-cancer overview of the genomic and transcriptomic alterations of FASTK genes. FASTK, FASTKD1, FASTKD3 and FASTKD5 showed the highest rates of genetic alterations. FASTK and FASTKD3 alterations consisted mainly of amplifications that were seen in more than 8% of ovarian and lung cancers, respectively. FASTKD1 and FASTKD5 were the most frequently mutated FASTK genes, and the mutations were identified in 5–7% of uterine cancers, as well as in 4% of melanomas. Our results also showed that the mRNA levels of all FASTK members were strongly upregulated in esophageal, stomach, liver and lung cancers. Finally, the protein-protein interaction network for FASTK proteins uncovers the interaction of FASTK, FASTKD2, FASTKD4 and FASTKD5 with cancer signaling pathways. These results serve as a starting point for future research into the potential of the FASTK family members as diagnostic and therapeutic targets for certain types of cancer.
PB MDPI
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59455
UL https://uvadoc.uva.es/handle/10324/59455
LA eng
NO International Journal Molecular Sciences, 2021, vol. 22, n. 21, 11337
NO Producción Científica
DS UVaDOC
RD 23-nov-2024