RT info:eu-repo/semantics/article
T1 Metronomic anti-cancer therapy: A multimodal therapy governed by the tumor microenvironment
A1 Muñoz Martínez, Raquel
A1 Girotti, Alessandra
A1 Hileeto, Denise
A1 Arias Vallejo, Francisco Javier
K1 Medicina
K1 Oncología
K1 Cancer Research
K1 Metronomic chemotherapy
K1 Tumor microenvironment
K1 Nanomedicine
K1 Quimioterapia metronómica
K1 Microentorno tumoral
K1 Nanomedicina
K1 3207.13 Oncología
AB The concept of cancer as a systemic disease, and the therapeutic implications of this, has gained special relevance. This concept encompasses the interactions between tumor and stromal cells and their microenvironment in the complex setting of primary tumors and metastases. These factors determine cellular co-evolution in time and space, contribute to tumor progression, and could counteract therapeutic effects. Additionally, cancer therapies can induce cellular and molecular responses in the tumor and host that allow them to escape therapy and promote tumor progression. In this study, we describe the vascular network, tumor-infiltrated immune cells, and cancer-associated fibroblasts as sources of heterogeneity and plasticity in the tumor microenvironment, and their influence on cancer progression. We also discuss tumor and host responses to the chemotherapy regimen, at the maximum tolerated dose, mainly targeting cancer cells, and a multimodal metronomic chemotherapy approach targeting both cancer cells and their microenvironment. In a combination therapy context, metronomic chemotherapy exhibits antimetastatic efficacy with low toxicity but is not exempt from resistance mechanisms. As such, a better understanding of the interactions between the components of the tumor microenvironment could improve the selection of drug combinations and schedules, as well as the use of nano-therapeutic agents against certain malignancies.
PB MDPI
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59533
UL https://uvadoc.uva.es/handle/10324/59533
LA eng
NO Cancers, 2021, vol. 13, n. 21, 5414
NO Producción Científica
DS UVaDOC
RD 07-ago-2024