RT info:eu-repo/semantics/article
T1 Cell therapy for colorectal cancer: The promise of chimeric antigen receptor (CAR)-T cells
A1 Aparicio Fernández, Cristina
A1 Belver Jiménez, Marina
A1 Enríquez, Lucía
A1 Espeso, Francisco
A1 Núñez Llorente, Lucía
A1 Sánchez García, Ana María de los Ángeles
A1 Fuente García, Miguel Ángel de la
A1 González-Vallinas Garrachón, Margarita
K1 Medicina
K1 Oncología
K1 Cancer Research
K1 Colorectal cancer
K1 CAR-T cells
K1 Immunotherapy
K1 Neoantigens
K1 Cáncer colorrectal
K1 Células CAR-T
K1 Inmunoterapia
K1 Neoantígenos
K1 3201.01 Oncología
AB Colorectal cancer (CRC) is a global public health problem as it is the third most prevalent and the second most lethal cancer worldwide. Major efforts are underway to understand its molecular pathways as well as to define the tumour-associated antigens (TAAs) and tumour-specific antigens (TSAs) or neoantigens, in order to develop an effective treatment. Cell therapies are currently gaining importance, and more specifically chimeric antigen receptor (CAR)-T cell therapy, in which genetically modified T cells are redirected against the tumour antigen of interest. This immunotherapy has emerged as one of the most promising advances in cancer treatment, having successfully demonstrated its efficacy in haematological malignancies. However, in solid tumours, such as colon cancer, it is proving difficult to achieve the same results due to the shortage of TSAs, on-target off-tumour effects, low CAR-T cell infiltration and the immunosuppressive microenvironment. To address these challenges in CRC, new approaches are proposed, including combined therapies, the regional administration of CAR-T cells and more complex CAR structures, among others. This review comprehensively summarises the current landscape of CAR-T cell therapy in CRC from the potential tumour targets to the preclinical studies and clinical trials, as well as the limitations and future perspectives of this novel antitumour strategy.
PB MDPI
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59536
UL https://uvadoc.uva.es/handle/10324/59536
LA eng
NO International Journal Molecular Science, 2021, vol. 22, n. 21, 11781
NO Producción Científica
DS UVaDOC
RD 26-dic-2024