RT info:eu-repo/semantics/article
T1 Correlation between antibiotic consumption and resistance of invasive streptococcus pneumoniae
A1 Čižman, Milan
A1 Mioč, Verica
A1 Bajec, Tom
A1 Paragi, Metka
A1 Kastrin, Tamara
A1 Carita Gonçalves, José Manuel
K1 Bacterias
K1 Antibióticos
K1 Infectious Diseases
K1 S. pneumoniae
K1 Resistance
K1 Antibiotic
K1 Prescription rate
K1 Resistencia
K1 Antibiótico
K1 Tasa de prescripción
K1 2414.01 Antibióticos
K1 2414.04 Bacteriología
AB There is a lack of long-term studies that correlate different metrics of antibiotic consumption and resistance of invasive S. pneumoniae. The present study aims to investigate the correlation between national outpatients total antibiotic, penicillin and broad spectrum penicillins consumption expressed in daily doses per 1000 inhabitants per day (DID) with the ATC/DDDs, WHO version of 2019 (new version) and 2018 (old version), number of prescriptions per 1000 inhabitants per year (RxIDs) and number of packages per 1000 inhabitant per day (PIDs) with the resistance of invasive S. pneumoniae in Slovenia in the period from 2000 to 2018. The prevalence of penicillin resistance of invasive S. pneumoniae decreased by 47.13%, from 19.1% to 10.1%. Decline of resistance showed the highest correlation (R = 0.86) between RxIDs followed by PID (R = 0.85) and resistance of S. pneumoniae. Higher correlation between total use of antibiotics expressed in DID WHO version 2019 (R = 0.80) than for WHO version 2018 (R = 0.78) was found. Very high (R = 0.84) correlation between use of β-lactams expressed in PID, and RxIDs (R = 0.82) and reasonable (R = 0.59) correlation expressed in DIDs version 2019 was shown as well. The consumption of broad -spectrum penicillins (J01CA and J01CR02) expressed in PID (R = 0.72) and RxIDs (0.57) correlated significantly with the resistance of S. pneumoniae as well. A new finding of this study is that RxIDs correlated better with the resistance of S. pneumoniae than total consumption of antibiotics expressed in DID and significant correlations exist between use of broad-spectrum penicillins expressed in PID and RxIDs.
PB MDPI
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59552
UL https://uvadoc.uva.es/handle/10324/59552
LA eng
NO Antibiotics, 2021, vol. 10, n.7, 758
NO Producción Científica
DS UVaDOC
RD 24-dic-2024