RT info:eu-repo/semantics/article
T1 Genetic profile in genes associated with cardiorespiratory fitness in elite Spanish male endurance athletes
A1 Varillas Delgado, David
A1 Tellería Orriols, Juan José
A1 Coso Garrigós, Juan del
K1 Endurance
K1 Physical fitness
K1 Sports medicine
K1 Sports - Physiological aspects
K1 Deportistas - España
K1 Deportistas - Genética
K1 Human genetics
AB Background: most of the research concerning the influence of genetics on endurance performance has been carried out by investigating target genes separately. However, endurance performance is a complex trait that can stem from the interaction of several genes. The objective of this study was to compare the frequencies of polymorphisms in target genes involving cardiorespiratory functioning in elite endurance athletes vs. non-athlete controls. Methods: genotypic frequencies were determined in 123 elite endurance athletes and in 122 non-athletes. Genotyping of ACE (rs4340), NOS3 (rs2070744 and rs1799983), ADRA2a (rs1800544 and rs553668), ADRB2 (rs1042713 and rs1042714), and BDKRB2 (rs5810761) was performed by polymerase chain reaction. The total genotype score (TGS: from 0 to 100 arbitrary units; a.u.) was calculated from the genotype score in each polymorphism. Results: the mean TGS in non-athletes (47.72 ± 11.29 a.u.) was similar to elite endurance athletes (46.54 ± 11.32 a.u., p = 0.415). The distribution of TGS frequencies were also similar in non-athletes and elite endurance athletes (p = 0.333). There was no TGS cut-off point to discriminate being elite endurance athletes. Conclusions: the genetic profile in the selected genes was similar in elite endurance athletes and in controls, suggesting that the combination of these genes does not determine endurance performance.
PB MDPI
SN 2073-4425
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59570
UL https://uvadoc.uva.es/handle/10324/59570
LA eng
NO Genes, 2021, Vol. 12, Nº. 8, 1230
NO Producción Científica
DS UVaDOC
RD 25-nov-2024