RT info:eu-repo/semantics/article
T1 Modulation of mitochondrial Ca2+ uptake by estrogen receptor agonists and antagonists
A1 Domínguez Lobatón, María Carmen
A1 Vay, Laura
A1 Hernández San Miguel, Esther
A1 Santo Domingo, Jaime
A1 Moreno Díaz-Calderón, Alfredo
A1 Montero Zoccola, María Teresa
A1 Álvarez Martín, Javier
K1 Hormonas femeninas - Absorción y adsorción
K1 Calcio - Efectos fisiológicos
AB Ca2+ uptake by mitochondria is a key element in the control ofcellular Ca2+ homeostasis andCa2+-dependent phenomena. It has been known for many years that this Ca2+ uptake is mediated bythe mitochondrial Ca2+ uniporter, a specific Ca2+ channel ofthe inner mitochondrial membrane. Wehave shown previously that this channel is strongly activated by a series ofnatural phytoestrogenicflavonoids. We show here that several agonists and antagonists of estrogen receptors (ERs) alsomodulate the activity ofthe uniporter.
PB Nature Publishing Group
SN 0007-1188
YR 2005
FD 2005
LK http://uvadoc.uva.es/handle/10324/5969
UL http://uvadoc.uva.es/handle/10324/5969
LA eng
NO British Journal of Pharmacology, 2005, vol. 145, p. 862-871
NO Producción Científica
DS UVaDOC
RD 24-nov-2024