RT info:eu-repo/semantics/article
T1 Changing the reaction pathway of Silyl-Prins cyclization by switching the lewis acid: Application to the synthesis of an antinociceptive compound
A1 Díez Poza, Carlos
A1 Fernández Peña, Laura
A1 González Andrés, Paula
A1 Barbero Pérez, María Asunción
K1 Química
K1 Química orgánica
K1 Catalysis
K1 Synthesis of tetrahydropyrans
K1 Lewis acid
K1 Antinociceptive
K1 Síntesis de tetrahidropiranos
K1 Ácido de Lewis
K1 Antinociceptivo
K1 2306 Química Orgánica
AB Developing new procedures for the synthesis of tetrahydropyrans in a very stereoselective manner is of great importance for the synthesis of THP-containing natural products. Here, we report an interesting protocol for the synthesis of polysubstituted halogenated tetrahydropyrans by silyl-Prins cyclization of vinylsilyl alcohols, in which the nature of the Lewis acid determines the outcome of the process. The methodology has been applied to the synthesis of a known antinociceptive.
PB American Chemical Society
SN 0022-3263
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/59704
UL https://uvadoc.uva.es/handle/10324/59704
LA eng
NO The Journal of Organic Chemistry, 2023, vol. 88, n. 11, pp. 6776–6783
NO Producción Científica
DS UVaDOC
RD 08-ago-2024