RT info:eu-repo/semantics/article
T1 Embryonic cerebrospinal fluid influence in the subependymal neurogenic niche in adult mouse hippocampus
A1 Madrigal Fernández, Miguel Ángel
A1 Martín Villamor, Pedro Gabriel
A1 Lamus Molina, José Francisco
A1 Fernández Gómez, José María Fidel
A1 Gato Casado, Ángel Luis
A1 Alonso Revuelta, María Isabel
K1 Neurosciences
K1 Neurology
K1 Hippocampus
K1 Cerebrospinal fluid
K1 Neurogenesis
K1 Hipocampo
K1 Fluido cerebroespinal
K1 Neurogénesis
K1 2490 Neurociencias
K1 3205.07 Neurología
AB The adult mouse hippocampal neurogenic niche is a complex structure which is not completely understood. It has mainly been related to the Subgranular layer of the dentate gyrus; however, as a result of differential neural stem cell populations reported in the subventricular zone of the lateral ventricle and associated with the hippocampus, the possibility remains of a multifocal niche reproducing developmental stages. Here, using a set of molecular markers for neural precursors, we describe in the adult mouse brain hippocampus the existence of a disperse population of neural precursors in the Subependymal Zone, the Dentate Migratory Stream and the hilus; these display dynamic behaviour compatible with neurogenesis. This supports the idea that the adult hippocampal niche cannot be restricted to the dentate gyrus subgranular layer. In other neurogenic niches such as the Subventricular Zone, a functional periventricular dependence has been shown due to the ability to respond to embryonic cerebro-spinal fluid. In this study, we demonstrate that neural precursors from the three areas studied (Sub-ependymal Zone, Dentate Migratory Stream and hilus) are able to modify their behaviour by increasing neurogenesis in a locally differential manner. Our results are compatible with the persistence in the adult mouse hippocampus of a neurogenic niche with the same spatial structure as that seen during development and early postnatal stages.
PB Elsevier
SN 0040-8166
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/59712
UL https://uvadoc.uva.es/handle/10324/59712
LA eng
NO Tissue and Cell, 2023, Volume 82, 102120
NO Producción Científica
DS UVaDOC
RD 26-dic-2024