RT info:eu-repo/semantics/article
T1 Calcium dynamics in the secretory granules of neuroendocrine cells
A1 Álvarez Martín, Javier
K1 Calcio en el organismo
AB Cellular Ca2+signaling results from a complex interplay among a variety of Ca2+ fluxes going across theplasma membrane and across the membranes of several organelles, together with the buffering effect oflarge numbers of Ca2+-binding sites distributed along the cell architecture. Endoplasmic and sarcoplasmicreticulum, mitochondria and even nucleus have all been involved in cellular Ca2+ signaling, and themechanisms for Ca2+ uptake and release from these organelles are well known. In neuroendocrine cells,the secretory granules also constitute a very important Ca2+-storing organelle, and the possible role ofthe stored Ca2+ as a trigger for secretion has attracted considerable attention. However, this possibility isfrequently overlooked, and the main reason for that is that there is still considerable uncertainty on themain questions related with granular Ca2+ dynamics, e.g., the free granular [Ca2+], the physical state ofthe stored Ca2+ or the mechanisms for Ca2+ accumulation and release from the granules. This review willgive a critical overview of the present state of knowledge and the main conflicting points on secretorygranule Ca2+ homeostasis in neuroendocrine cells.
PB Elsevier Ltd.
SN 0143-4160
YR 2012
FD 2012
LK http://uvadoc.uva.es/handle/10324/5986
UL http://uvadoc.uva.es/handle/10324/5986
LA eng
NO Cell Calcium, 2012, vol. 51, p. 331-337
NO Producción Científica
DS UVaDOC
RD 22-nov-2024