RT info:eu-repo/semantics/article
T1 Modulation of insulin sensitivity by insulin-degrading enzyme
A1 González Casimiro, Carlos Manuel
A1 Merino Antolín, Beatriz
A1 Casanueva Álvarez, Elena
A1 Postigo Casado, Tamara
A1 Cámara Torres, Patricia
A1 Fernández Díaz, Cristina María
A1 Leissring, Malcolm A.
A1 Cózar Castellano, Irene
A1 Perdomo Hernández, Germán
K1 Insulin
K1 Insulin resistance
K1 Insulina - Receptores
K1 Páncreas
K1 Liver
K1 Liver - Diseases
K1 Glucose
K1 Insulin-degrading enzyme
K1 Enzima degradadora de insulina
K1 32 Ciencias Médicas
K1 2415 Biología Molecular
K1 
AB Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed metalloprotease that degrades insulin and several other intermediate-size peptides. For many decades, IDE had been assumed to be involved primarily in hepatic insulin clearance, a key process that regulates availability of circulating insulin levels for peripheral tissues. Emerging evidence, however, suggests that IDE has several other important physiological functions relevant to glucose and insulin homeostasis, including the regulation of insulin secretion from pancreatic β-cells. Investigation of mice with tissue-specific genetic deletion of Ide in the liver and pancreatic β-cells (L-IDE-KO and B-IDE-KO mice, respectively) has revealed additional roles for IDE in the regulation of hepatic insulin action and sensitivity. In this review, we discuss current knowledge about IDE’s function as a regulator of insulin secretion and hepatic insulin sensitivity, both evaluating the classical view of IDE as an insulin protease and also exploring evidence for several non-proteolytic functions. Insulin proteostasis and insulin sensitivity have both been highlighted as targets controlling blood sugar levels in type 2 diabetes, so a clearer understanding the physiological functions of IDE in pancreas and liver could led to the development of novel therapeutics for the treatment of this disease.
PB MDPI
SN 2227-9059
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59878
UL https://uvadoc.uva.es/handle/10324/59878
LA eng
NO Biomedicines, 2021, Vol. 9, Nº. 1, 86
NO Producción Científica
DS UVaDOC
RD 24-nov-2024