RT info:eu-repo/semantics/doctoralThesis T1 ¿Es importante la determinación de virus respiratorios en pacientes sépticos postoperatorios?: Un estudio observacional preliminar previo a la pandemia de SARS-CoV2 A1 Balbás Álvarez, Sara A2 Universidad de Valladolid. Escuela de Doctorado K1 Medicina K1 Critical care medicine K1 Respiratory virus K1 Virus respiratorios K1 32 Ciencias Médicas AB Respiratory viruses are part of the normal microbiota of the respiratory tract, which sometimes cause infection with/without respiratory insufficiency and the need for hospital or ICU admission. The aim of this study is to determine the prevalence of respiratory viruses in nontransplanted postoperative septic patients as well as lymphocyte count influence in their presence and its relationship to mortality. 223 nontransplanted postsurgical septic patients were recruited on the Intensive Care Unit (ICU) at Hospital Clínico Universitario de Valladolid prior to the SARS-COV-2 pandemic. Patients were split into 2 groups according to the presence/absence of respiratory viruses. Multivariate logistic regression analysis was used to identify independent factors related to positive respiratory virus PCR test. Respiratory viruses were isolated in 28.7% of patients. 28-day mortality was not significantly different between virus-positive and virus-negative groups. Logistic regression analysis revealed that lymphocyte count ≤ 928/µl is independently associated with a positive PCR result [OR 3.76, 95% CI (1.71–8.26), P = .001] adjusted by platelet count over 128,500/µL [OR 4.27, 95% CI (1.92–9.50) P < .001] and the presence of hypertension [OR 2.69, 95% CI (1.13–6.36) P = .025] as confounding variables. Respiratory viruses’ detection by using PCR in respiratory samples of nontransplanted postoperative septic patients is frequent. These preliminary results revealed that the presence of lymphopenia on sepsis diagnosis is independently associated to a positive virus result, which is not related to a higher 28-day mortality YR 2021 FD 2021 LK https://uvadoc.uva.es/handle/10324/59895 UL https://uvadoc.uva.es/handle/10324/59895 LA spa NO Escuela de Doctorado DS UVaDOC RD 28-jun-2024