RT info:eu-repo/semantics/doctoralThesis
T1 Prevalencia, severidad y costes asociados al diagnóstico de pacientes con esteatosis hepática metabólica (EHmet)
A1 Mora Cuadrado, Natalia
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Esteatosis hepática
K1 Liver
K1 Hepática
K1 Fatty
K1 Esteatosis
K1 32 Ciencias Médicas
AB Metabolic associated fatty liver disease (MAFLD) is a major public health problem and is currently the most common cause of chronic liver disease in our environment, associated with the parallel increase in the global epidemic of obesity and type 2 diabetes (DM-2).  There are hardly any data on the real prevalence in our environment, the workload in hepatology consultations, severity of the disease, and the expenses derived from the care of these patients.The objectives of the study are to determine the prevalence of MAFLD in the outpatient clinics of University Clinical Hospital of Valladolid (HCUV), to analyze the risk factors associated with its presence and severity, as well as to describe the medical resources used and derived costs. Design: prospective cohort study of patients with suspected chronic liver disease referred to the HCUV. Epidemiological and analytical variables, genetic polymorphisms, as well as the diagnostic methods used and the costs derived from the diagnosis of these patients were analyzed.The prevalence of MAFLD as a cause of chronic liver disease in our consultations was 42.7%, being the most frequent cause of chronic liver disease in our setting. The risk factors associated with MAFLD in our study are obesity, dyslipidemia, arterial hypertension, DM-2 and metabolic syndrome, as well as the genetic polymorphisms of PNPLA3, TNF-alpha and CNR1, which are also associated with more severe forms of the disease. Non-invasive methods allow diagnosis in most patients. Although liver biopsy is still necessary in some cases, it doubles the cost associated with the care of these patients.
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59897
UL https://uvadoc.uva.es/handle/10324/59897
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 07-ago-2024