RT info:eu-repo/semantics/article
T1 Antiviral activity of ribosome-inactivating proteins
A1 Citores González, Lucía
A1 Iglesias Álvarez, María del Rosario
A1 Ferreras Rodríguez, José Miguel
K1 Virus
K1 Virology
K1 Immunology
K1 Plantas - Biotecnología
K1 Plantas Transgénicas
K1 Virus diseases
K1 Proteins - Synthesis
K1 Proteínas
K1 Ribosomes - Structure
K1 Virus - Tratamiento
K1 Ribosome-inactivating protein
K1 Proteínas inactivadoras de ribosomas
K1 Virus-resistant transgenic plant
K1 Plantas transgénicas resistentes a virus
K1 rRNA glycosylase
K1 
K1 2420 Virología
K1 2412 Inmunología
K1 2302 Bioquímica
AB Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the difficulty in treating viral infections. On the other hand, there is a growing need to control crop diseases without resorting to the use of phytosanitary products which are very harmful to the environment and in this respect, RIPs have been shown as a promising tool that can be used to obtain transgenic plants resistant to viruses. The way in which RIPs exert their antiviral effect continues to be the subject of intense research and several mechanisms of action have been proposed. The purpose of this review is to examine the research studies that deal with this matter, placing special emphasis on the most recent findings.
PB MDPI
SN 2072-6651
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59913
UL https://uvadoc.uva.es/handle/10324/59913
LA eng
NO Toxins, 2021, Vol. 13, Nº. 2, 80
NO Producción Científica
DS UVaDOC
RD 12-sep-2024