RT info:eu-repo/semantics/article
T1 Marine heterocyclic compounds that modulate intracellular calcium signals: Chemistry and synthesis approaches
A1 González Andrés, Paula
A1 Fernández Peña, Laura
A1 Díez Poza, Carlos
A1 Villalobos Jorge, Carlos
A1 Núñez Llorente, Lucía
A1 Barbero Pérez, María Asunción
K1 Organic chemistry
K1 Drugs
K1 Drogas
K1 Heterocyclic compounds
K1 Compuestos heterocíclicos
K1 Pharmacology/Toxicology
K1 Calcio en el organismo
K1 Calcio, Conductos de
K1 Organic compounds - Synthesis
K1 Compuestos orgánicos - Síntesis
K1 Clinical chemistry
K1 Drug development
K1 Medicamentos - Investigación
K1 Marine drugs
K1 Drogas marinas
K1 3209 Farmacología
K1 3214 Toxicología
AB Intracellular Ca2+ plays a pivotal role in the control of a large series of cell functions in all types of cells, from neurotransmitter release and muscle contraction to gene expression, cell proliferation and cell death. Ca2+ is transported through specific channels and transporters in the plasma membrane and subcellular organelles such as the endoplasmic reticulum and mitochondria. Therefore, dysregulation of intracellular Ca2+ homeostasis may lead to cell dysfunction and disease. Accordingly, chemical compounds from natural origin and/or synthesis targeting directly or indirectly these channels and proteins may be of interest for the treatment of cell dysfunction and disease. In this review, we show an overview of a group of marine drugs that, from the structural point of view, contain one or various heterocyclic units in their core structure, and from the biological side, they have a direct influence on the transport of calcium in the cell. The marine compounds covered in this review are divided into three groups, which correspond with their direct biological activity, such as compounds with a direct influence in the calcium channel, compounds with a direct effect on the cytoskeleton and drugs with an effect on cancer cell proliferation. For each target, we describe its bioactive properties and synthetic approaches. The wide variety of chemical structures compiled in this review and their significant medical properties may attract the attention of many different researchers.
PB MDPI
SN 1660-3397
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59922
UL https://uvadoc.uva.es/handle/10324/59922
LA eng
NO Marine Drugs, 2021, Vol. 19, Nº. 2, 78
NO Producción Científica
DS UVaDOC
RD 18-nov-2024