RT info:eu-repo/semantics/article
T1 Impact of preoperative total proteins and glycated hemoglobin on recurrences after early colorectal cancer
A1 Castro Alija, María José
A1 Jiménez Pérez, José María
A1 López Vallecillo, María
A1 Cao Torija, María José
A1 Santos Torres, Jair
A1 López, Alberto
A1 Moreno, Ana
A1 Ruiz-Tovar Polo, Jaime
K1 Surgical oncology
K1 Cancer Research
K1 Oncology
K1 Colorectal Surgery
K1 Rectum - Surgery
K1 Càncer colorectal
K1 Recto - Cáncer
K1 Colon - Cáncer
K1 Outcome assessment (Medical care)
K1 Proteins
K1 Proteínas
K1 Glycosylated hemoglobin - Measurement
K1 Nutrition
K1 32 Ciencias Médicas
K1 3201.01 Oncología
AB Background: The outcome of colorectal cancer is mostly based on TNM classification. There are several factors determining that patients with the same tumoral stage present different outcomes. The nutritional status has been related to the immunological response and may affect the oncologic results. The purpose of this study was to determine if preoperative nutritional parameters may predict the oncologic outcome in patients with early colorectal cancer. Methods: A prospective observational study of patients undergoing elective surgery for colorectal cancer was performed with stage I. Preoperative nutritional assessment included glycemic and lipid profiles, total proteins, and albumin levels. These parameters were correlated with tumoral recurrence during a follow-up of at least 24 months. Results: During the period of study, 744 patients were operated on and 228 (30.6%) followed the inclusion criteria for this study. Recurrence rate was 5.7% (13 patients). Patients with hypoproteinemia showed a 7.8-fold greater risk of recurrence during the first 24 months after surgery [OR 7.8 (CI95% 1.3–48), p = 0.012]. Patients with glycated hemoglobin levels (HbA1c) > 6.2% showed a 2.3 increased risk of recurrence [OR 2.3 (CI95% 1.1–4.7; p = 0.01]. Conclusions: Preoperative values of total proteins and HbA1c correlate with the recurrence rate in early colorectal cancer.
PB MDPI
SN 2072-6643
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59956
UL https://uvadoc.uva.es/handle/10324/59956
LA eng
NO Nutrients, 2021, Vol. 13, Nª. 2, 711
NO Producción Científica
DS UVaDOC
RD 30-jun-2024