RT info:eu-repo/semantics/article
T1 Circulating AQP4 levels in patients with cerebral amyloid angiopathy-associated intracerebral hemorrhage
A1 Marazuela, Paula
A1 Bonaterra Pastra, Anna
A1 Faura, Júlia
A1 Penalba, Anna
A1 Pizarro, Jesús
A1 Pancorbo, Olalla
A1 Rodríguez Luna, David
A1 Vert, Carla
A1 Rovira, Alex
A1 Pujadas, Francesc
A1 Freijo Guerrero, María del Mar
A1 Tur, Silvia
A1 Martínez Zabaleta, Maite
A1 Cardona Portela, Pere
A1 Vera, Rocío
A1 Lebrato Hernández, Lucía
A1 Arenillas Lara, Juan Francisco
A1 Pérez Sánchez, Soledad
A1 Montaner, Joan
A1 Delgado, Pilar
A1 Hernández Guillamon, Mar
K1 Brain - Hemorrhage
K1 Neurology
K1 Cerebrovascular diseases
K1 Enfermedades cerebrovasculares
K1 Magnetic resonance
K1 Resonancia magnética
K1 Angiopatia
K1 Cerebro - Anomalias
K1 Neurosurgery
K1 Aquaporin 4
K1 Cerebral amyloid angiopathy
K1 3205.07 Neurología
K1 3207.11 Neuropatología
K1 32 Ciencias Médicas
AB Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA–ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.
PB MDPI
SN 2077-0383
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/59965
UL https://uvadoc.uva.es/handle/10324/59965
LA eng
NO Journal of Clinical Medicine, 2021, Vol. 10, Nº. 5, 989
NO Producción Científica
DS UVaDOC
RD 24-nov-2024