RT info:eu-repo/semantics/article
T1 A systematic review and meta-analysis of premenstrual syndrome with special emphasis on herbal medicine and nutritional supplements
A1 Sultana, Arshiya
A1 Heyat, Md Belal Bin
A1 Rahman, Khaleequr
A1 Kunnavil, Radhika
A1 Fazmiya, Mohamed Joonus Aynul
A1 Akhtar, Faijan
A1 Sumbul, null
A1 Vidal Mazón, Juan Luis
A1 Rodríguez, Carmen Lili
A1 Torre Díez, Isabel de la
K1 Dietary supplements
K1 Dietética
K1 Women - Health and hygiene
K1 Mujeres - Sanidad e Higiene
K1 Herbs - Therapeutic use
K1 Medicinal plants
K1 Menstrual cycle
K1 Ciclo menstrual
K1 Reproductive health
K1 Salud reproductiva
K1 Meta-analysis
K1 Estadística matemática
K1 Software measurement
K1 Programas y sistemas de programación - Medición
K1 PMS
K1 Síndrome premenstrual
K1 32 Ciencias Médicas
K1 1209.01 Estadística Analítica
AB Herbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectiveness in alleviating premenstrual symptoms. The published randomized controlled trials (RCTs) were extracted from Google scholar, PubMed, Scopus and PROSPERO databases. The risk of bias in randomized trials was assessed by Cochrane risk-of-bias tool. The main outcome parameters were analysed separately based on the Premenstrual Symptom Screening Tool and PMTS and DRSP scores. Secondary parameters of somatic, psychological, and behavioural subscale symptoms of PSST were also analysed. Data synthesis was performed assuming a random-effects model, and standardized mean difference (SMDs) was analysed using SPSS version 28.0.0 (IBM, Armonk, NY, USA). A total of 754 articles were screened, and 15 RCTs were included (n = 1211 patients). Primary results for participants randomized to an intervention reported reduced PSST (n = 9), PMTS (n = 2), and DSR (n = 4) scores with (SMD = −1.44; 95% CI: −1.72 to −1.17), (SMD = −1.69; 95% CI: −3.80 to 0.42) and (SMD = 2.86; 95% CI: 1.02 to 4.69) verses comparator with substantial heterogeneity. Physical (SMD = −1.61; 95% CI = −2.56 to −0.66), behavioural (SMD = −0.60; 95% CI = −1.55 to 0.35) and mood (SMD = 0.57; 95% CI = −0.96 to 2.11) subscale symptom groupings of PSST displayed similar findings. Fifty-three studies (n = 8) were considered at low risk of bias with high quality. Mild adverse events were reported by four RCTs. Based on the existing evidence, herbal medicine and nutritional supplements may be effective and safe for PMS.
PB MDPI
SN 1424-8247
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/60116
UL https://uvadoc.uva.es/handle/10324/60116
LA eng
NO Pharmaceuticals, 2022, Vol. 15, Nº. 11, 1371
NO Producción Científica
DS UVaDOC
RD 11-jul-2024