RT info:eu-repo/semantics/article T1 Accelerometer cut-points for physical activity assessment in adults with mild to moderate huntington’s disease: A cross-sectional multicentre study A1 Simón Vicente, Lucía A1 Rivadeneyra Posadas, Jéssica A1 Soto Célix, María A1 Raya González, Javier A1 Castillo Alvira, Daniel A1 Calvo, Sara A1 Collazo, Carla A1 Rodríguez Fernández, Alejandro A1 Fahed, Vitoria S. A1 Mariscal, Natividad A1 García Bustillo, Álvaro A1 Aguado, Laura A1 Cubo, Esther K1 Energy metabolism K1 Metabolismo energético K1 Rehabilitation K1 Rehabilitación K1 Neurosciences K1 Huntington's disease K1 Corea (Enfermedad) K1 Calorimetry K1 Calorimetría K1 Exercise - Health aspects K1 Ejercicio - Aspectos de salud K1 Running K1 Marcha (Deportes) K1 Accelerometry K1 Acelerometría K1 2490 Neurociencias K1 3205.07 Neurología AB Accelerometers can estimate the intensity, frequency, and duration of physical activity in healthy adults. Although thresholds to distinguish varying levels of activity intensity using the Actigraph wGT3X-B have been established for the general population, their accuracy for Huntington’s disease (HD) is unknown. We aimed to define and cross-validate accelerometer cut-points for different walking speeds in adults with mild to moderate HD. A cross-sectional, multicentre, case-control, observational study was conducted with a convenience sample of 13 symptomatic ambulatory HD participants. The accelerometer was placed around the right hip, and a heart monitor was fitted around the chest to monitor heart rate variability. Participants walked on a treadmill at three speeds with light, moderate and vigorous intensities. Correlation and receiver operation curve analyses were performed between the accelerometer magnitude vector with relative oxygen and heart rate. Optimal cut-points for walking speeds of 3.2 km/h were ≤2852; 5.2 km/h: >2852 to ≤4117, and in increments until their maximum velocity: >4117. Our results support the application of the disease-specific cut-points for quantifying physical activity in patients with mild to moderate HD and promoting healthy lifestyle interventions. PB MDPI SN 1660-4601 YR 2022 FD 2022 LK https://uvadoc.uva.es/handle/10324/60163 UL https://uvadoc.uva.es/handle/10324/60163 LA eng NO International Journal of Environmental Research and Public Health, 2022, Vol. 19, Nº. 22, 14834 NO Producción Científica DS UVaDOC RD 16-ago-2024