RT info:eu-repo/semantics/article
T1 Non-adherence to antidepressant treatment and related factors in a region of Spain: A population-based registry study
A1 Pedrosa Naudín, M. Aránzazu
A1 Gutiérrez Abejón, Eduardo
A1 Herrera Gómez, Francisco Magno
A1 Fernández Lázaro, Diego
A1 Álvarez González, Francisco Javier
K1 Antidepressants
K1 Antidepresivos
K1 Drug utilization
K1 Medicamentos - Uso
K1 Psychiatry
K1 Pharmacy
K1 Psychopharmacology
K1 Depression
K1 Depresión mental
K1 Anxiety
K1 Ansiedad
K1 Psychopathology
K1 Psychotropic drugs
K1 Drogas psicotrópicas
K1 3209 Farmacología
K1 3211 Psiquiatría
K1 3209.09 Psicofarmacología
AB Antidepressants are a commonly prescribed psychotropic medication, and their use has increased in recent years. Medication non-adherence in patients with mental disorders is associated with worse health outcomes. A population-based registry study to assess antidepressant non-adherence during 2021 has been carried out. An indirect method based on the medication possession ratio (MPR) has been utilized. Patients with a MPR under 80% were classified as non-adherent. A multivariate logistic regression to identify non-adherence predictors has been used, considering sociodemographic (age, sex, institutionalization and urbanicity) and health related variables (diagnostics, antidepressant class, multiple prescribers, and polypharmacy). In 2021, 10.6% of the Castile and Leon population used antidepressants. These patients were institutionalized (7.29%), living in urban areas (63.44%), polymedicated with multiple prescribers (57.07%), and using serotonin selective reuptake inhibitors (SSRIs) (54.77%), other antidepressants (46.82%) or tricyclic antidepressants (TCAs) (13.76%). Antidepressants were prescribed mainly for depression (36.73%) and anxiety (29.24%). Non-adherence to antidepressants was more frequent in men (20.56%) than in woman (19.59%) and decreased with increasing age (32% up to 17 years old vs. 13.76% over 80 years old). TCAs were associated with the highest prevalence of non-adherence (23.99%), followed by SSRIs (20.19%) and other antidepressants (18.5%). Predictors of non-adherence in patients on antidepressants were: living in urban areas, using TCAs, and pain occurrence. Non-adherence to antidepressants decreases with aging. Being female, institutionalization, being polymedicated and having depression/anxiety alongside another psychiatric diagnosis are protective factors against non-adherence. The MPR is a robust indicator for the clinician to identify non-adherent patients for monitoring, and adopt any necessary corrective actions.
PB MDPI
SN 1999-4923
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/60298
UL https://uvadoc.uva.es/handle/10324/60298
LA eng
NO Pharmaceutics, 2022, Vol. 14, Nº. 12, 2696
NO Producción Científica
DS UVaDOC
RD 15-may-2024