RT info:eu-repo/semantics/doctoralThesis
T1 Influencia de la exposición solar y la dieta en los niveles séricos de vitamina D de dos poblaciones geográficas diferentes comparando dos técnicas analíticas
A1 Fernández Vicente, Maite
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Endocrinology
K1 Bromatología
K1 Vitaminas
K1 Vitamin D
K1 Vitamina D
K1 Calcium homeostasis
K1 Homeostasis del calcio
K1 Nutrition
K1 Nutrición
K1 3206.13 Vitaminas
AB Vitamin D plays a fundamental role in calcium homeostasis and bone metabolism. Although the diet provides a small percentage of this vitamin, it mainly comes from cutaneous synthesis through the action of sunlight. Therefore, variations in exposure to this radiation modify serum levels. We studied two different analytes of vitamin D in the healthy Spanish population and the influence of seasonality, climate, latitude, diet and obesity, calculated using percent body fat and/or body mass index (BMI), on its levels.This work is a cross-sectional, descriptive study. A total of 206 blood donors from Burgos and Valencia between 18-60 years of age were recruited during March-April and October-November 2018. Total and free serum 25-hydroxycholecalciferol (25(OH)D) were analyzed.After summer, total and free serum 25(OH)D médium levels were 24.31 ± 5.25 ng/mL and 5.01 ± 1.25 pg/mL in Burgos and 25.99 ± 6.87 ng/mL and 8.97 ± 2.82 pg/mL in Valencia. After winter, they were 17.66 ± 5.04 ng/mL and 4.08 ± 0.66 ng/mL in Burgos and 21.38 ± 3.77 ng/mL and 7.23 ± 2.44 ng/mL in Valencia. The seasonal changes were statistically significant for both components studied both in the sample as a whole and in the separate populations. The differences found between the two populations in total and free 25(OH)D levels were statistically significant except for total 25(OH)D after summer (24.07 ng/mL vs. 26.03 ng/mL; p=0.408). Latitude was also shown to be a factor that influences concentrations of both analytes in summer and winter. Diet, however, was not an influential factor on the levels of any of the analytes: R2 = 0.01, p = 0.19 for total 25(OH)D, and R2 < 0.01, p = 0.69 for free 25(OH)D. The correlations between the two analytical techniques showed positive and statistically significant results, with a Pearson's correlation coefficient = 0.47 (95% CI: 0.36-0.57), p < 0.01.Our study shows lower vitamin D levels tan expected for a healthy Spanish population. Seasonality, climate, and latitude were demonstrated to influence total and free 25(OH)D levels. This was not the case for vitamin D intake. The correlations between the two analytical techniques and the results of them reinforces the usefulness of free 25(OH)D as a determinant of vitamin D status.
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/60327
UL https://uvadoc.uva.es/handle/10324/60327
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 22-nov-2024