RT info:eu-repo/semantics/article
T1 Influence of renal dysfunction on the differential behaviour of procalcitonin for the diagnosis of postoperative infection in cardiac surgery
A1 Varga Martínez, Olga de la
A1 Martín Fernández, Marta
A1 Heredia Rodríguez, María
A1 Ceballos Laita, Luis
A1 Cubero Gallego, Héctor
A1 Priede Vimbela, Juan Manuel
A1 Bardají Carrillo, Miguel
A1 Sánchez de Prada, Laura
A1 López Herrero, Rocio
A1 Jorge Monjas, Pablo
A1 Tamayo Gómez, Eduardo
A1 Gómez Sánchez, Esther
K1 Heart - Surgery - Patients - Medical care
K1 Cardiac surgery
K1 Cardiology
K1 Cardiovascular, aparato - Cirugía
K1 Corazón - Cirugía
K1 Kidneys - Diseases
K1 Riñones - Enfermedades
K1 Nephrology
K1 Biochemical markers
K1 Nosocomial infections
K1 Infecciones de hospital
K1 Procalcitonin
K1 Procalcitonina
K1 3205.01 Cardiología
K1 3205.06 Nefrología
AB Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng/mL p < 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction.
PB MDPI
SN 2077-0383
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/60425
UL https://uvadoc.uva.es/handle/10324/60425
LA eng
NO Journal of Clinical Medicine, 2022, Vol. 11, Nº. 24, 7274
NO Producción Científica
DS UVaDOC
RD 06-ago-2024