RT info:eu-repo/semantics/article
T1 Effects of Withania somnifera (Ashwagandha) on hematological and biochemical markers, hormonal behavior, and oxidant response in healthy adults: A systematic review
A1 Gómez Afonso, Adrián
A1 Fernández Lázaro, Diego
A1 Adams, David P.
A1 Monserdà Vilaró, Aniol
A1 Fernández Lázaro, César I.
K1 Withania somnifera
K1 Ashwagandha
K1 Plant supplement
K1 Biomarkers
K1 Healthy adults
K1 2302 Bioquímica
AB Purpose of Review Withania somnifera (L.) Dunal (Ws) is a common herb plant that has been used for centuries to treat a widerange of conditions, particularly certain chronic diseases due to its antidiabetic, cardioprotective, antistress, and chondroprotec-tive effects, among many others. No conclusive evidence, however, exists about the potential health effects of Ws in adults with-out chronic conditions. We aimed to evaluate the current evidence on the health benefits of Ws supplementation in healthy adults.Recent Findings Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines,we systematically reviewed studies indexed in Web of Science, Scopus, and PubMed to assess the effects of Ws on hema-tological and biochemical markers, hormonal behavior, and oxidant response in healthy adults. Original articles publishedup to March 5, 2022, with a controlled trial design or pre-post intervention design, in which supplementation of Ws wascompared to a control group or data prior to intervention were included. Among 2,421 records identified in the search, 10studies met the inclusion criteria. Overall, most of the studies reported beneficial effects of the Ws supplementation, andno serious adverse events were reported. Participants supplemented with Ws displayed reduced levels of oxidative stressand inflammation, and counterbalanced hormone levels. No evidence of the beneficial effects of Ws supplementation onhematological markers was reported.Summary Ws supplementation appears to be safe, may regulate hormone levels, and has potent anti-inflammatory and anti-oxidant effects. However, further studies are needed to elucidate the relevance of its application.
PB Springer
SN 2161-3311
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/60531
UL https://uvadoc.uva.es/handle/10324/60531
LA eng
NO Current Nutrition Reports, 2023.
NO Producción Científica
DS UVaDOC
RD 27-dic-2024