RT info:eu-repo/semantics/doctoralThesis
T1 New methods for organocatalyzed asymmetric synthesis of spirocyclic pyrazolones from pyrazole-4,5-diones and N-Boc protected pyrazolinone ketimines
A1 Gil Ordoñez, Marta
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Química orgánica
K1 pyrazolone
K1 pirazolona
K1 spirocycles
K1 espirociclos
K1 NHCs
K1 carbenos
K1 organocatalysis
K1 organocatálisis
K1 2306 Química Orgánica
AB Pyrazole derivatives are an interesting class of heterocycles known for the wide range of applications they enable. Among all of them, spirocyclic pyrazolones and 4-amino-5-pyrazolone derivatives belong to a wide family of compounds with well-known pharmacological properties (antitumoral, analgesic). Due to this, chemists have devoted efforts to the asymmetric synthesis of these compounds. Whereas pyrazolin-5-ones and unsaturated pyrazolones have been extensively used as starting materials in asymmetric reactions, pyrazolin-4,5-diones and their corresponding N-Boc ketimines derivatives have hardly been used. On the other hand, asymmetric organocatalysis constitutes one of the most useful, effective and eco-friendly strategies for the asymmetric synthesis of organic compounds, and, because of this, it is a growing field.Consequently, the main objective in this Doctoral Thesis is the development of new methods for the asymmetric synthesis of spirocyclic pyrazolones and 4-amino-5-pirazolone derivatives from pyrazolin-4,5-diones and their N-Boc ketimines derivatives. Two different strategies will be used: covalent catalysis, by using chiral N-heterocyclic carbenes, and hydrogen bonding catalysis through the use of chiral bifunctional squaramides.
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/60598
UL https://uvadoc.uva.es/handle/10324/60598
LA eng
NO Escuela de Doctorado
DS UVaDOC
RD 13-jul-2024