RT info:eu-repo/semantics/article
T1 Effects of a short-term meal replacement hypocaloric diet in subjects with obesity and high fatty liver index
A1 Luis Román, Daniel Antonio de
A1 Primo Martín, David
A1 Izaola Jauregui, Olatz
A1 López Gómez, Juan José
K1 Fatty liver
K1 Liver - Diseases
K1 Hígado - Enfermedades
K1 Obesity
K1 Obesidad
K1 Nutrition
K1 Nutrition disorders
K1 Enfermedades de la nutrición
K1 Dietetics
K1 Dietética
K1 Regímenes alimentarios
K1 Enzymes
K1 Enzimas
K1 3205.02 Endocrinología
K1 3206 Ciencias de la Nutrición
AB Introduction: Dietary changes play a role in metabolic response of patients with metabolic-associated fatty liver disease, and there is little evidence on the use of partial meal replacement (pMR) diets in this pathology. Aim: We decided to evaluate the modifications in transaminases levels after a pMR hypocaloric diet in subjects with obesity and elevated fatty liver index (FLI). Material and methods: A sample of 606 patients with obesity and FLI ≥ 60 were enrolled and treated during 3 months with a pMR diet. Patients were divided as group I (Alanine amino transferase (ALT) normal) or group II (ALT ≥ 43 UI/L). Results: Body mass index, body weight, total fat mass, waist circumference, blood pressure, fasting glucose, total cholesterol, Low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, Homeostasis Model assessment (HOMA-IR), and FLI index improved significantly in the total group with pMR diet, without differences between group I and II. ALT, aspartate aminotransferase activity (AST), Gama glutamine transferase (GGT), and ratios of AST/ALT improved in both groups, too. This improvement was higher in group II (deltas group I vs. deltas group II); ALT (−4.2 ± 0.9 UI/L vs. −32.1 ± 5.7 UI/L: p = 0.01), AST (−4.8 ± 1.8 UI/L vs. −14.1 ± 1.9 UI/L: p = 0.02), GGT (−4.8 ± 1.4 UI/L vs. −37.1 ± 4.2 UI/L: p = 0.01), and AST/ALT ratio (−0.04 ± 0.002 units vs. −0.19 ± 0.04 units: p = 0.01). Conclusions: We reported that a pMR diet is an effective method to lose weight and to improve metabolic parameters in patients with obesity and high FLI. The decrease in liver parameters was greater in patients with ALT ≥ 43 UI/L.
PB MDPI
SN 2072-6643
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/60606
UL https://uvadoc.uva.es/handle/10324/60606
LA eng
NO Nutrients, 2022, Vol. 14, Nº. 24, 5353
NO Producción Científica
DS UVaDOC
RD 17-jul-2024