RT info:eu-repo/semantics/article
T1 Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress
A1 Ganfornina Álvarez, María Dolores
A1 Carmo, Sonia do
A1 Lora, Jose M.
A1 Torres Schumann, Sonia
A1 Vogel, Marci
A1 Allhorn, Maria
A1 González, Constancio
A1 Bastiani, Michael J.
A1 Rassart, Eric
A1 Sánchez Romero, Diego
K1 Nervioso, sistema  - Enfermedades
K1 Lípidos
AB Many nervous system pathologies are associated withincreased levels of apolipoprotein D (ApoD), a lipocalinalso expressed during normal development and aging.An ApoD homologous gene inDrosophila, Glial Lazarillo,regulates resistance to stress, and neurodegeneration in theaging brain. Here we study for the first time the protectivepotential of ApoD in a vertebrate model organism. Lossof mouse ApoD function increases the sensitivity tooxidative stress and the levels of brain lipid peroxidation,and impairs locomotor and learning abilities. HumanApoD overexpression in the mouse brain produces oppositeeffects, increasing survival and preventing the raise ofbrain lipid peroxides after oxidant treatment. Theseobservations, together with its transcriptional up-regulationin the brain upon oxidative insult, identify ApoD as an acuteresponse protein with a protective and therefore beneficialfunction mediated by the control of peroxidated lipids.Key words: learning, lipid peroxidation, lipocalin, locomotorbehavior, paraquat, oxidative stress.
PB Blackwell Publishing
SN 1474-9718
YR 2008
FD 2008
LK http://uvadoc.uva.es/handle/10324/6077
UL http://uvadoc.uva.es/handle/10324/6077
LA eng
NO Aging Cell, 2008, vol. 7, p. 506-515
NO Producción Científica
DS UVaDOC
RD 24-nov-2024