RT info:eu-repo/semantics/article
T1 Molecular Characterization and Developmental Expression Pattern of the Chicken Apolipoprotein D Gene: Implications for the Evolution of Vertebrate Lipocalins
A1 Ganfornina Álvarez, María Dolores
A1 Sánchez Romero, Diego
A1 Pagano, Aldo
A1 Tonachini, Laura
A1 Descalzi-Cancedda, Fiorella
A1 Martínez, Salvador
K1 Nervioso, Sistema - Evolución
K1 Embriología
K1 Células clonales
AB The insect Lazarillo and the mammalian apolipoprotein D (ApoD) are orthologous members of the lipocalinprotein family. We report the cloning and embryonic expression of chicken ApoD, the first molecularlycharacterized nonmammalian ApoD. We also report the ApoD expression in mouse during postnataldevelopment and some novel aspects of the expression of the paralogous lipocalin prostaglandin D-synthase(PGDS) and discuss these results in view of the lipocalin family evolution in vertebrates. ApoD is expressedin subsets of central nervous system (CNS) neurons and glia during late chicken embryogenesis. Contraryto mouse ApoD, no expression appears in neural crest-derived cephalic mesenchyme and blood vesselpericytes. Also, ApoD is expressed in developing chicken feathers. These expressions are corroborated byquantitative reverse transcriptase-polymerase chain reaction profiles. ApoD is expressed during mousepostnatal development in a subset of CNS neurons, astrocytes and oligodendrocytes, but also in meningesand pericytes. Chicken PGDS is expressed in brain meninges and perivascular cells. Our results suggestthat the amniote last common ancestor expressed ApoD and PGDS in the brain during embryogenesis. ApoDappears restricted to ectodermal derivatives, whereas PGDS is expressed by derivatives of the three germlayers.
PB Wiley-Liss
SN 1058-8388
YR 2005
FD 2005
LK http://uvadoc.uva.es/handle/10324/6078
UL http://uvadoc.uva.es/handle/10324/6078
LA eng
NO Developmental Dynamics, 2005, vol. 232, p. 191-199
NO Producción Científica
DS UVaDOC
RD 27-dic-2024