RT info:eu-repo/semantics/article
T1 Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
A1 Ruiz, Mario
A1 Sánchez Romero, Diego
A1 Canal, Inmaculada
A1 Acebes, Angel
A1 Ganfornina Álvarez, María Dolores
K1 Lipocainas
K1 Células - Envejecimiento
AB Apolipoprotein D (ApoD), a member of the Lipocalin family, is the gene most up-regulated with age in themammalian brain. Its expression strongly correlates with aging-associated neurodegenerative and metabolicdiseases. Two homologues of ApoD expressed in the Drosophila brain, Glial Lazarillo (GLaz) and NeuralLazarillo (NLaz), are known to alter longevity in male flies. However, sex differences in the aging process havenot been explored so far for these genes. Here we demonstrate that NLaz alters lifespan in both sexes, butunexpectedly the lack of GLaz influences longevity in a sex-specific way, reducing longevity in males but notin females. While NLaz has metabolic functions similar to ApoD, the regulation of GLaz expression upon agingis the closest to ApoD in the aging brain. A multivariate analysis of physiological parameters relevant tolifespan modulation uncovers both common and specialized functions for the two Lipocalins, and reveals thatchanges in protein homeostasis account for the observed sex-specific patterns of longevity. The response tooxidative stress and accumulation of lipid peroxides are among their common functions, while thetranscriptional and behavioral response to starvation, the pattern of daily locomotor activity, storage of fatalong aging, fertility, and courtship behavior differentiate NLaz from GLaz mutants. We also demonstrate thatfood composition is an important environmental parameter influencing stress resistance and reproductivephenotypes of both Lipocalin mutants. Since ApoD shares many properties with the common ancestor ofinvertebrate Lipocalins, we must benefit from this global comparison with both GLaz and NLaz to understandthe complex functions of ApoD in mammalian aging and neurodegeneration.
PB Elsevier
SN 0531-5565
YR 2011
FD 2011
LK http://uvadoc.uva.es/handle/10324/6079
UL http://uvadoc.uva.es/handle/10324/6079
LA eng
NO Experimental Gerontology, 2011, vol. 46, p. 579-589
NO Producción Científica
DS UVaDOC
RD 28-abr-2024