RT info:eu-repo/semantics/article
T1 Decreased kainate receptors in the hippocampus of apolipoprotein D knockout mice
A1 Boer, Simone
A1 Sánchez Romero, Diego
A1 Reinieren, Ivo
A1 Boom, Tom van den
A1 Udawela, Madhara
A1 Scarr, Elizabeth
A1 Ganfornina Álvarez, María Dolores
A1 Dean, Brian
K1 Neuropsicofarmacología
AB Apolipoprotein D (ApoD) has many actions critical to maintaining mammalian CNS function. It is thereforesignificant that levels of ApoD have been shown to be altered in the CNS of subjects with schizophrenia,suggesting a role for ApoD in the pathophysiology of the disorder. There is also a large body of evidence thatcortical and hippocampal glutamatergic, serotonergic and cholinergic systems are affected by the pathophysiologyof schizophrenia. Thus, we decided to use in vitro radioligand binding and autoradiography tomeasure levelsof ionotropic glutamate, somemuscarinic and serotonin 2Areceptors in theCNS ofApoD-/- and isogenic wild-typemice. These studies revealed a 20% decrease(mean±SEM: 104±10.2 vs. 130±10.4 fmol/mg ETE) in the densityof kainate receptors in the CA 2–3 of the ApoD-/- mice. In addition therewas a global decrease inAMPA receptors(F1,214=4.67, pb0.05) and a global increase in muscarinic M2/M4 receptors (F1,208=22.77, pb0.0001) in theApoD-/- mice that did not reach significance in any single cytoarchitectural region. We conclude thatglutamatergic pathways seem to be particularly affected in ApoD-/- mice and this may contribute to the changesin learning and memory, motor tasks and orientation-based tasks observed in these animals, all of which involveglutamatergic neurotransmission.
PB Elsevier
SN 0278-5846
YR 2010
FD 2010
LK http://uvadoc.uva.es/handle/10324/6103
UL http://uvadoc.uva.es/handle/10324/6103
LA eng
NO Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2010, vol. 34, p. 271-278
NO Producción Científica
DS UVaDOC
RD 24-nov-2024