RT info:eu-repo/semantics/article
T1 Corneal regeneration using adipose-derived mesenchymal stem cells
A1 Alió del Barrio, Jorge L.
A1 De La Mata Sampedro, Ana
A1 Miguel, María P. de
A1 Arnalich Montiel, Francisco
A1 Nieto Miguel, Teresa
A1 El Zarif, Mona
A1 Cadenas Martín, Marta
A1 López Paniagua, Marina
A1 Galindo de la Rosa, Sara
A1 Calonge, Margarita
A1 Alió, Jorge L.
K1 Stem cells
K1 Células madre
K1 Cell Biology
K1 Retina - Diseases
K1 Retina - Enfemedades
K1 Regenerative medicine
K1 Medicina regenerativa
K1 Ophthalmology
K1 Cornea - Transplantation
K1 Córnea - Trasplante
K1 Cellular therapy
K1 Mesenchymal stem cells
K1 Eye - Diseases
K1 Ojos - Enfermedades
K1 Adiposo, Tejido
K1 2407 Biología Celular
K1 3201.09 Oftalmología
AB Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important advantage of being easily obtained (in an autologous manner) from low invasive procedures, rendering a high number of multipotent stem cells with the potential to differentiate into several cellular lineages, to show immunomodulatory properties, and to promote tissue regeneration by a paracrine action through the secretion of extracellular vesicles containing trophic factors. This secretome is currently being investigated as a potential source for a cell-free based regenerative therapy for human tissues, which would significantly reduce the involved costs, risks and law regulations, allowing for a broader application in real clinical practice. In the current article, we will review the existing preclinical and human clinical evidence regarding the use of such adipose-derived mesenchymal stem cells for the regeneration of the three main layers of the human cornea: the epithelium (derived from the surface ectoderm), the stroma (derived from the neural crest mesenchyme), and the endothelium (derived from the neural crest cells).
PB MDPI
SN 2073-4409
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/61051
UL https://uvadoc.uva.es/handle/10324/61051
LA eng
NO Cells 2022, Vol. 11, Nº. 16,  2549
NO Producción Científica
DS UVaDOC
RD 17-jul-2024