RT info:eu-repo/semantics/article
T1 Potential satellite cell-linked biomarkers in aging skeletal muscle tissue: Proteomics and proteogenomics to monitor sarcopenia
A1 Fernández Lázaro, Diego
A1 Garrosa, Evelina
A1 Seco Calvo, Jesús
A1 Garrosa García, Manuel
K1 Muscles - Diseases
K1 Músculos - Enfermedades
K1 Muscles - Aging
K1 Músculos - Envejecimiento
K1 Musculoskeletal diseases in old age
K1 Muscular atrophy
K1 Atrofia muscular
K1 Proteomics
K1 Proteomica
K1 Medical genetics
K1 Muscles - Biopsy
K1 Cell Biology
K1 Aging
K1 Envejecimiento
K1 Biomarkers
K1 3201.02 Genética Clínica
K1 2407 Biología Celular
AB Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging which causes an involution of muscle function and strength. Satellite cells (Sc) are myogenic stem cells, which are activated by injury or stress, and repair muscle tissue. With advancing age, there is a decrease in the efficiency of the regenerative response of Sc. Diagnosis occurs with the Sp established by direct assessments of muscle. However, the detection of biomarkers in real-time biofluids by liquid biopsy could represent a step-change in the understanding of the molecular biology and heterogeneity of Sp. A total of 13 potential proteogenomic biomarkers of Sp by their physiological and biological interaction with Sc have been previously described in the literature. Increases in the expression of GDF11, PGC-1α, Sirt1, Pax7, Pax3, Myf5, MyoD, CD34, MyoG, and activation of Notch signaling stimulate Sc activity and proliferation, which could modulate and delay Sp progression. On the contrary, intensified expression of GDF8, p16INK4a, Mrf4, and activation of the Wnt pathway would contribute to early Sp development by directly inducing reduced and/or altered Sc function, which would attenuate the restorative capacity of skeletal muscle. Additionally, tissue biopsy remains an important diagnostic tool. Proteomic profiling of aged muscle tissues has shown shifts toward protein isoforms characteristic of a fast-to-slow transition process and an elevated number of oxidized proteins. In addition, a strong association between age and plasma values of growth differentiation factor 15 (GDF-15) has been described and serpin family A member 3 (serpin A3n) was more secreted by atrophied muscle cells. The identification of these new biomarkers holds the potential to change personalized medicine because it could predict in real time the course of Sp by monitoring its evolution and assessing responses to potential therapeutic strategies.
PB MDPI
SN 2227-7382
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/61098
UL https://uvadoc.uva.es/handle/10324/61098
LA eng
NO Proteomes,  2022, Vol. 10, Nº. 3, 29
NO Producción Científica
DS UVaDOC
RD 22-nov-2024