RT info:eu-repo/semantics/article
T1 Effects of citrulline supplementation on different aerobic exercise performance outcomes: A systematic review and meta-analysis
A1 Viribay, Aitor
A1 Fernández Lázaro, Diego
A1 Fernández Landa, Julen
A1 Castañeda Babarro, Arkaitz
A1 Sánchez Collado, Pilar
A1 Mielgo Ayuso, Juan Francisco
K1 Nutrition
K1 Sports - Physiological aspects
K1 Athletes - Nutrition
K1 Atletas - Nutrición
K1 Food additives
K1 Aditivos alimentarios
K1 Nutrición - Alimentos
K1 Dietetics
K1 Nitric oxide
K1 Oxido nitrico
K1 Exercise
K1 Ejercicio físico
K1 Endurance sports
K1 Deportes de resistencia
K1 Meta-analysis
K1 Citrulline
K1 Citrulina
K1 3104.06 Nutrición
K1 2411.06 Fisiología del Ejercicio
AB Supplementation with Citrulline (Cit) has been shown to have a positive impact on aerobic exercise performance and related outcomes such as lactate, oxygen uptake (VO2) kinetics, and the rate of perceived exertion (RPE), probably due to its relationship to endogenous nitric oxide production. However, current research has shown this to be controversial. The main objective of this systematic review and meta-analysis was to analyze and assess the effects of Cit supplementation on aerobic exercise performance and related outcomes, as well as to show the most suitable doses and timing of ingestion. A structured literature search was carried out by the PRISMA® (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and PICOS guidelines in the following databases: Pubmed/Medline, Scopus, and Web of Science (WOS). A total of 10 studies were included in the analysis, all of which exclusively compared the effects of Cit supplementation with those of a placebo group on aerobic performance, lactate, VO2, and the RPE. Those articles that used other supplements and measured other outcomes were excluded. The meta-analysis was carried out using Hedges’ g random effects model and pooled standardized mean differences (SMD). The results showed no positive effects of Cit supplementation on aerobic performance (pooled SMD = 0.15; 95% CI (−0.02 to 0.32); I2, 0%; p = 0.08), the RPE (pooled SMD = −0.03; 95% CI (−0.43 to 0.38); I2, 49%; p = 0.9), VO2 kinetics (pooled SMD = 0.01; 95% CI (−0.16 to 0.17); I2, 0%; p = 0.94), and lactate (pooled SMD = 0.25; 95% CI (−0.10 to 0.59); I2, 0%; p = 0.16). In conclusion, Cit supplementation did not prove to have any benefits for aerobic exercise performance and related outcomes. Where chronic protocols seemed to show a positive tendency, more studies in the field are needed to better understand the effects.
PB MDPI
SN 2072-6643
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/61151
UL https://uvadoc.uva.es/handle/10324/61151
LA eng
NO Nutrients, 2022, Vol. 14, Nº. 17, 3479
NO Producción Científica
DS UVaDOC
RD 11-jul-2024