RT info:eu-repo/semantics/article T1 Diacutaneous fibrolysis intervention in patients with mild to moderate carpal tunnel syndrome may avoid severe cases in elderly: A randomized controlled trial A1 Jiménez del Barrio, Sandra A1 Ceballos Laita, Luis A1 Bueno Gracia, Elena A1 Rodríguez Marco, Sonia A1 Caudevilla Polo, Santos A1 Estébanez de Miguel, Elena K1 Ultrasonic imaging K1 Ultrasonography K1 Ultrasonografía K1 Physical therapy K1 Traumatology K1 Orthopedics K1 Wrist - Wounds and injuries K1 Muñeca (Anatomia) - Lesiones y heridas K1 Hand - Wounds and injuries K1 Mano - Lesiones y heridas K1 Carpal Tunnel Syndrome K1 Síndrome del túnel carpiano K1 Diacutaneous Fibrolysis K1 Fibrólisis diacutánea K1 3213.11 Fisioterapia K1 3213.15 Traumatología AB Background: Carpal Tunnel Syndrome (CTS) mainly affects adults of working age. The prevalence of severe cases is higher in elderly patients (>65 years old). Clinical guidelines recommend conservative treatment as the best option in the initial stages of CTS to avoid severe cases. Diacutaneous Fibrolysis (DF) has demonstrated to improve nerve conduction studies and mechanosensitivity. The main purpose was to quantify changes in the cross-sectional area (CSA) of the median nerve, transversal carpal ligament (TCL) thickness, numbness intensity, and the subjective assessment of clinical change after DF treatment in patients with CTS. Methods: a double-blind, randomized, placebo-controlled trial was designed. A number of 44 patients (60 wrists) with CTS were randomized to the DF group or the sham group. CSA and TCL thickness variables were registered by ultrasound. Clinical variables were assessed by the visual analogue scale and GROC scale. SPSS version 24.0 for MAC was used for statistical analysis. The group by time interaction between groups was analyzed using two-way repeated measures analysis of variance. Results: The DF group reduced CSA with a mean of 0.45 mm2 (IC 95% 0.05 to 0.86) and TCL thickness with a mean reduction of 0.4 mm (IC 95% 0.6 to 2.1) compared to the sham group (p < 0.01, p < 0,03, respectively). Additionally, the DF group decreased the numbness intensity with a mean reduction of 3.47 (IC 95% 2.50 to 4.44, p < 0.01) and showed a statistically significant improvement on the GROC scale (p < 0.01). Conclusions: DF treatment may significantly reduce CSA and TCL thickness, numbness intensity, and improved clinical perspective. DF applied in patients with mild to moderate CTS may prevent the progression of the disease as they age. PB MDPI SN 1660-4601 YR 2022 FD 2022 LK https://uvadoc.uva.es/handle/10324/61201 UL https://uvadoc.uva.es/handle/10324/61201 LA eng NO International Journal of Environmental Research and Public Health, 2022, Vol. 19, Nº. 17, 10983 NO Producción Científica DS UVaDOC RD 28-jun-2024