RT info:eu-repo/semantics/article
T1 Inflammation, nitro‐oxidative stress and altered autonomic outflow in obstructive sleep apnoea: an assault on homeostasis
A1 Rocher Martín, María Asunción
A1 Aaronson, Philip Irving
K1 Carotid body
K1 Inflammation
K1 Oxidative stress
K1 2302.04 Genética Bioquímica
AB The carotid body (CB) acts as a chemoreceptor which, when stimulated by arterial hypoxia, hypercapnia or acidosis, releases transmitters which stimulate sensory afferents that signal to the nucleus tractus solitarius (NTS). Acting through the rostral ventrolateral medulla (RVLM), this initiates a chemoreflex, stimulating autonomic efferents that orchestrate compensatory cardiorespiratory responses. Unfortunately, chronic intermittent hypoxia (CIH), which occurs in obstructive sleep apnoea (OSA), subverts the beneficial homeostatic function of this chemoreflex, causing increases in basal and hypoxia-induced transmitter release by the CB and sensitizing the cardiorespiratory centres it acts through. This causes a chronic sympathetic overdrive, contributing to the pathophysiological consequences of OSA such as heart failure, resistant hypertension and insulin resistance. [Texto del artículo]
PB Wiley
SN 0022-3751
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/61238
UL https://uvadoc.uva.es/handle/10324/61238
LA eng
NO The Journal of Physiology, 2023.
NO Producción Científica
DS UVaDOC
RD 23-nov-2024