RT info:eu-repo/semantics/article
T1 25-hydroxyvitamin D serum levels linked to single nucleotide polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in skeletal muscle aging in institutionalized elderly men not supplemented with vitamin D
A1 Fernández Lázaro, Diego
A1 García Hernández, Juan Luis
A1 Lumbreras, Eva
A1 Mielgo Ayuso, Juan Francisco
A1 Seco Calvo, Jesús
K1 Older people - Care
K1 Personas de edad - Cuidados
K1 Aging
K1 Envejecimiento
K1 Muscles - Aging
K1 Músculos - Envejecimiento
K1 Muscular atrophy
K1 Atrofia muscular
K1 Geriatrics
K1 25(OH)vitamin D
K1 Vitamin D
K1 Vitamina D
K1 Genetics
K1 Genetica
K1 3201.07 Geriatría
K1 2407 Biología Celular
AB Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging that results in an involution of muscle function and strength. Vitamin D deficiency is a common health problem worldwide, especially among the elderly, and hypovitaminosis D leads to musculoskeletal disorders. The aim of this study was to evaluate the impact and presence of a possible linkage between Single Nucleotide Polymorphisms (SNPs) CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs2228570), serum 25-OH/D concentrations and the link with the degree of sarcopenia in 19 institutionalized elderly men not supplemented with vitamin D. Levels of 25-OH vitamin D were quantified with a commercial enzyme-linked immunosorbent assay kit and 3 SNPs were genotyped with KASPar assays. Significant differences in 25-OH/D concentration were determined between the bi-allelic combinations of rs228679 and rs228570. We detected statistically significant weak positive correlations between the AA (rs10741657 and rs228570) and TT (rs228679) and alleles and 25-OH/D and the probability of having higher 25-OH/D concentrations was 2- to 3-fold higher. However, the GG alleles of the 3 SNPs showed that the probability of having optimal 25-0H/D concentrations decreases by 32% for rs10741657, 38% for rs228679, and 74% for rs228570, showing a strong negative correlation between the degree of sarcopenia and 25-OH/D levels. Allelic variations in CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs10741657) affect vitamin D levels and decisively influence the degree of sarcopenia in institutionalized elderly people.
PB MDPI
SN 1422-0067
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/61506
UL https://uvadoc.uva.es/handle/10324/61506
LA eng
NO International Journal of Molecular Sciences, 2022, Vol. 23, Nº. 19, 11846
NO Producción Científica
DS UVaDOC
RD 23-jun-2024