RT info:eu-repo/semantics/article
T1 Induced pluripotent stem cells, a stepping stone to in vitro human models of hearing loss
A1 Durán Alonso, María Beatriz
A1 Petković, Hrvoje
K1 Hearing loss
K1 Trastornos de la audición
K1 Deafness
K1 Sordera
K1 Stem cells
K1 Células madre
K1 Cell Biology
K1 Inner ear
K1 Oido interno
K1 Otorhinolaryngology
K1 Otorrinolaringología
K1 Genetics
K1 Genetica
K1 2407 Biología Celular
K1 3201.04 Patología Clínica
AB Hearing loss is the most prevalent sensorineural impairment in humans. Yet despite very active research, no effective therapy other than the cochlear implant has reached the clinic. Main reasons for this failure are the multifactorial nature of the disorder, its heterogeneity, and a late onset that hinders the identification of etiological factors. Another problem is the lack of human samples such that practically all the work has been conducted on animals. Although highly valuable data have been obtained from such models, there is the risk that inter-species differences exist that may compromise the relevance of the gathered data. Human-based models are therefore direly needed. The irruption of human induced pluripotent stem cell technologies in the field of hearing research offers the possibility to generate an array of otic cell models of human origin; these may enable the identification of guiding signalling cues during inner ear development and of the mechanisms that lead from genetic alterations to pathology. These models will also be extremely valuable when conducting ototoxicity analyses and when exploring new avenues towards regeneration in the inner ear. This review summarises some of the work that has already been conducted with these cells and contemplates future possibilities.
PB MDPI
SN 2073-4409
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/61600
UL https://uvadoc.uva.es/handle/10324/61600
LA eng
NO Cells 2022, Vol. 11, Nº. 20, 3331
NO Producción Científica
DS UVaDOC
RD 24-nov-2024