RT info:eu-repo/semantics/article
T1 The relationship between angiogenic factors and energy metabolism in preeclampsia
A1 Abascal Saiz, Alejandra
A1 Duque Alcorta, Marta
A1 Fioravantti, Victoria
A1 Antolín, Eugenia
A1 Fuente Luelmo, Eva
A1 Haro, María
A1 Ramos Álvarez, María Pilar
A1 Perdomo Hernández, Germán
A1 Bartha, José Luis
K1 Hypertension in pregnancy
K1 Hipertensión en el embarazo
K1 Lipids Metabolism
K1 Lípidos - Metabolismo
K1 Esterification
K1 Esterificación
K1 Oxidation
K1 Oxidación
K1 Carbohydrates - Metabolism
K1 Hidratos de carbono - Metabolismo
K1 Placenta
K1 Preeclampsia
K1 Pregnancy
K1 Embarazo - Complicaciones y secuelas
K1 Gynecology & Obstetrics
K1 3201.08 Ginecología
AB Antiangiogenic factors are currently used for the prediction of preeclampsia. The present study aimed to evaluate the relationship between antiangiogenic factors and lipid and carbohydrate metabolism in maternal plasma and placenta. We analyzed 56 pregnant women, 30 healthy and 26 with preeclampsia (including early and late onset). We compared antiangiogenic factors soluble Fms-like Tyrosine Kinase-1 (sfLt-1), placental growth factor (PlGF), and soluble endoglin (sEng)), lipid and carbohydrate metabolism in maternal plasma, and lipid metabolism in the placenta from assays of fatty acid oxidation, fatty acid esterification, and triglyceride levels in all groups. Antiangiogenic factors sFlt-1, sFlt-1/PlGF ratio, and sEng showed a positive correlation with triglyceride, free fatty acid, and C-peptide maternal serum levels. However, there was no relationship between angiogenic factors and placental lipid metabolism parameters. Free fatty acids were predictive of elevated sFlt-1 and sEng, while C-peptide was predictive of an elevated sFlt1/PlGF ratio. The findings in this study generate a model to predict elevated antiangiogenic factor values and the relationship between them with different products of lipid and carbohydrate metabolism in maternal serum and placenta in preeclampsia.
PB MDPI
SN 2072-6643
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/61798
UL https://uvadoc.uva.es/handle/10324/61798
LA eng
NO Nutrients, 2022, Vol. 14, Nº. 10, 2172
NO Producción Científica
DS UVaDOC
RD 06-ago-2024