RT info:eu-repo/semantics/article
T1 Impact of oxygen delivery on the development of acute kidney injury in patients undergoing valve heart surgery
A1 Carrasco Serrano, Elena
A1 Jorge Monjas, Pablo
A1 Muñoz Moreno, María Fe
A1 Gómez Sánchez, Esther
A1 Priede Vimbela, Juan Manuel
A1 Bardají Carrillo, Miguel
A1 Cubero Gallego, Héctor
A1 Tamayo Gómez, Eduardo
A1 Ortega Loubon, Christian Joseph
K1 Nephrology
K1 Kidneys - Diseases
K1 Riñones - Enfermedades
K1 Cardiac surgery
K1 Cardiovascular, aparato -  Cirugía
K1 Heart - Surgery
K1 Corazón - Cirugía
K1 Cardiology
K1 Cardiopulmonary bypass
K1 3205.06 Nefrología
K1 3205.01 Cardiología
AB One of the strongest risk factors for death in individuals undergoing cardiac surgery is Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI). Although the minimum kidney oxygen delivery index (DO2i) during cardiopulmonary bypass (CPB) has been reported, the optimal threshold value has not yet been established. A prospective study was conducted from June 2012 to January 2016 to asses how DO2i influences the pathogenesis of CSA-AKI, as well as its most favorable cut-off value. DO2 levels were recorded at the beginning, middle, and end of the CPB. The association between DO2i and CSA-AKI was investigated using multivariable logistic regression analysis. The optimal cut-off of DO2i as a predictor of CSA-AKI was determined using Classification and Regression Tree (CART) analysis. A total of 782 consecutive patients were enrolled. Of these, 231 (29.5%) patients developed AKI. Optimal DO2i thresholds of 303 mL/min/m2 during the CPB and 295 mL/min/m2 at the end of the intervention were identified, which increased the odds of CSA-AKI almost two-fold (Odds Ratio (OR), 1.90; 95% CI, 1.12–3.24) during the surgery and maintained that risk (OR 1.94; 95% CI, 1.15–3.29) until the end. Low DO2i during cardiopulmonary bypass is a risk factor for CSA-AKI that cannot be ruled out. Continuous renal oxygen supply monitoring for adult patients could be a promising method for predicting AKI during CPB.
PB MDPI
SN 2077-0383
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/61799
UL https://uvadoc.uva.es/handle/10324/61799
LA eng
NO Journal of Clinical Medicine, 2022, Vol. 11, Nº. 11, 3046
NO Producción Científica
DS UVaDOC
RD 22-may-2024