RT info:eu-repo/semantics/article T1 Association of the APOA-5 genetic variant rs662799 with metabolic changes after an intervention for 9 months with a low-calorie diet with a Mediterranean profile A1 Luis Román, Daniel Antonio de A1 Primo Martín, David A1 Izaola Jauregui, Olatz A1 Aller de la Fuente, Rocío K1 Human genetics K1 Genética humana K1 Regímenes alimentarios K1 Nutrition K1 Nutrición K1 Dietetics K1 Dietética K1 Diet therapy K1 Diet K1 Dieta K1 Food Science K1 Triglycerides K1 Triglicéridos K1 3206 Ciencias de la Nutrición K1 32 Ciencias Médicas AB In cross-sectional studies, the genetic variant rs662799 of the APOA5 gene is associated with high serum triglyceride concentrations, and in some studies, the effect of short-term dietary interventions has been evaluated. The aim of the present investigation was to evaluate the role of this genetic variant in metabolic changes after the consumption of a low-calorie diet with a Mediterranean pattern for 9 months. A population of 269 Caucasian obese patients was recruited. Adiposity and biochemical parameters were measured at the beginning (basal level) and after 3 and 9 months of the dietary intervention. The rs662799 genotype was assessed with a dominant analysis (TT vs. CT + CC). The APOA5 variant distribution was: 88.1% (n = 237) (TT), 11.5% (n = 31) (TC) and 0.4% (n = 1) (CC). There were significant differences only in triglyceride levels at all times of the study between the genotype groups. After 3 and 9 months of dietary intervention, the following parameters improved in both genotype groups: adiposity parameters, systolic pressure, total cholesterol, LDL cholesterol, leptin, adiponectin and the leptin/adiponectin ratio. The intervention significantly decreased insulin levels, HOMA-IR and triglyceride levels in non-C allele carriers (Delta 9 months TT vs. TC + CC). i.e., insulin levels (delta: −3.8 + 0.3 UI/L vs. −1.2 + 0.2 UI/L; p = 0.02), HOMA-IR levels (delta: −1.2 + 0.2 units vs. −0.3 + 0.1 units; p = 0.02), triglyceride levels (delta: −19.3 + 4.2 mg/dL vs. −4.2 + 3.0 mg/dL; p = 0.02). In conclusion, non-C allele carriers of rs662799 of the APOA5 gene showed a decrease of triglyceride, insulin and HOMA-IR levels after consuming a low-calorie diet with a Mediterranean pattern; we did not observe this effect in C allele carriers, despite a significant weight loss. PB MDPI SN 2072-6643 YR 2022 FD 2022 LK https://uvadoc.uva.es/handle/10324/61852 UL https://uvadoc.uva.es/handle/10324/61852 LA eng NO Nutrients, 2022, Vol. 14, Nº. 12, 2427 NO Producción Científica DS UVaDOC RD 09-oct-2024