RT info:eu-repo/semantics/article
T1 Effect of vitamin C on tendinopathy recovery: A scoping review
A1 Noriega González, David César
A1 Drobnic, Franchek
A1 Caballero García, Alberto
A1 Roche Collado, Enrique
A1 Pérez Valdecantos, Daniel
A1 Córdova Martínez, Alfredo
K1 Vitamin C
K1 Vitamina C
K1 Tendons - Wounds and injuries
K1 Tendones - Lesiones y heridas
K1 Tendons - Diseases
K1 Tendinitis
K1 Collagen
K1 Colágeno
K1 Oxidative stress
K1 Estrés oxidativo
K1 Nutrition
K1 32 Ciencias Médicas
K1 3206.13 Vitaminas
K1 3206 Ciencias de la Nutrición
AB Tendinopathies represent 30–50% of all sports injuries. The tendon response is influenced by the load (volume, intensity, and frequency) that the tendon support, resulting in irritability and pain, among others. The main molecular component of tendons is collagen I (60–85%). The rest consist of glycosaminoglycans-proteoglycans, glycoproteins, and other collagen subtypes. This study’s aim was to critically evaluate the efficacy of vitamin C supplementation in the treatment of tendinopathies. At the same time, the study aims to determine the optimal conditions (dose and time) for vitamin C supplementation. A structured search was carried out in the SCOPUS, Medline (PubMed), and Web of Science (WOS) databases. The inclusion criteria took into account studies describing optimal tendon recovery when using vitamin C alone or in combination with other compounds. The study design was considered, including randomized, double-blind controlled, and parallel designs in animal models or humans. The main outcome is that vitamin C supplementation is potentially useful as a therapeutic approach for tendinopathy recovery. Vitamin C supplementation, alone or in combination with other products, increases collagen synthesis with a consequent improvement in the patient’s condition. On the other hand, vitamin C deficiency is mainly associated with a decrease in procollagen synthesis and reduced hydroxylation of proline and lysine residues, hindering the tendon repair process.
PB MDPI
SN 2072-6643
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/61891
UL https://uvadoc.uva.es/handle/10324/61891
LA eng
NO Nutrients, 2022, Vol. 14, Nº. 13, 2663
NO Producción Científica
DS UVaDOC
RD 17-jul-2024