RT info:eu-repo/semantics/bookPart
T1 Lipocalin Genes and Their Evolutionary History
A1 Sánchez Romero, Diego
A1 Ganfornina Álvarez, María Dolores
A1 Gutiérrez, Gabriel
A1 Gauthier-Jauneau, Anne-Christine
A1 Risler, Jean-Loup
A1 Salier, Jean-Philippe
K1 Lipocalinas
AB As extensively detailed elsewhere in this book, lipocalins exibit three characteristic features, which include: (i) an unusually low amino acid sequence similarity (typically 15-25% between paralogs) (ii) a highly conserved protein tertiary structure, and (iii) a similar arrangement of exons and introns in the coding sequence of their genes. These shared protein and gene features are overwhelming arguments for the existence of a single lipocalin ancestral gene that once extended into a family. The ancestral gene appears to have arisen in a group of bacteria, and possibly was inherited by eukaryotes as a result of genome fusion (see Chapter 4). Given this hypothetical beginning, lipocalins are expected to be found in all descendants of the eukaryotic common ancestor. Currently, and aside of prokaryotes, bona fide lipocalin have been recovered from a protoctist, a fungus, several plants, a nematode, several arthropods, a tunicate, a cephalochordate, and many examples of chordates. This review will first focus on the structure of lipocalin genes in eukaryotes, and then on our current view of the evolutionary hostory of this family.
PB Landes Bioscience
YR 2005
FD 2005
LK http://uvadoc.uva.es/handle/10324/6219
UL http://uvadoc.uva.es/handle/10324/6219
LA eng
NO Akerstrom, Bo; Borregard, Niels; Flower, Darren R.; Salier, Jean-Phillippe (coords.). Molecular Biology Intelligence Unit: Lipocalins. Georgetown: Texas, 2005, p. 5-16
NO Producción Científica
DS UVaDOC
RD 24-nov-2024