RT info:eu-repo/semantics/article
T1 L-Arginine and beetroot extract supplementation in the prevention of sarcopenia
A1 Córdova Martínez, Alfredo
A1 Caballero García, Alberto
A1 Bello Gutierrez, Hugo José
A1 Pons Biescas, Antoni
A1 Noriega González, David César
A1 Roche Collado, Enrique
K1 Aging
K1 Envejecimiento
K1 Creatine kinase
K1 Creatine
K1 Clinical nutrition
K1 Nutrición clínica
K1 Nutrition
K1 L-arginine
K1 Suplementos nutritivos
K1 Nitrate
K1 Nitratos
K1 Muscle strength
K1 Fuerza muscular
K1 Muscles - Aging
K1 Músculos - Envejecimiento
K1 Pharmacology
K1 3206 Ciencias de la Nutrición
K1 2402.15 Envejecimiento Somático
K1 3209 Farmacología
AB Aging is associated with a significant decline in neuromuscular function, leading to a reduction in muscle mass and strength. The aim of the present report was to evaluate the effect of supplementation with nitric oxide precursors (l-arginine and beetroot extract) in muscular function during a training period of 6 weeks in elderly men and women. The study (double-blind, placebo-controlled) involved 66 subjects randomly divided into three groups: placebo, arginine-supplemented and beetroot extract-supplemented. At the end of this period, no changes in anthropometric parameters were observed. Regarding other circulating parameters, urea levels were significantly (p < 0.05) lower in women of the beetroot-supplemented group (31.6 ± 5.9 mg/dL) compared to placebo (41.3 ± 8.5 mg/dL) after 6 weeks of training. In addition, the circulating creatine kinase activity, as an index of muscle functionality, was significantly (p < 0.05) higher in women of the arginine- (214.1 ± 162.2 mIU/L) compared to the beetroot-supplemented group (84.4 ± 36.8 mIU/L) at the end of intervention. No significant effects were noticed with l-arginine or beetroot extract supplementation regarding strength, endurance and SPPB index. Only beetroot extract supplementation improved physical fitness significantly (p < 0.05) in the sprint exercise in men after 6 weeks (2.33 ± 0.59 s) compared to the baseline (2.72 ± 0.41 s). In conclusion, beetroot seems to be more efficient during short-term training while supplementing, preserving muscle functionality in women (decreased levels of circulating creatine kinase) and with modest effects in men.
PB MDPI
SN 1424-8247
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/62264
UL https://uvadoc.uva.es/handle/10324/62264
LA eng
NO Pharmaceuticals, 2022, Vol. 15, Nº. 3, 290
NO Producción Científica
DS UVaDOC
RD 14-ene-2025