RT info:eu-repo/semantics/article
T1 Supercritical foaming and impregnation of polycaprolactone and polycaprolactone-hydroxyapatite composites with carvacrol
A1 Satpayeva, Alina
A1 Rojas, Adrián
A1 Tyrka, Marcin
A1 Ksepko, Ewelina
A1 Galotto, María José
A1 Zizovic, Irena
K1 Supercritical carbon dioxide
K1 Supercritical CO2
K1 Carbon dioxide
K1 Dióxido de carbono
K1 Polycaprolactone
K1 Polymers
K1 Biodegradable
K1 Hydroxyapatite
K1 Scaffold
K1 Foam
K1 Espumas poliméricas
K1 Carvacrol
K1 Antibacterial agents
K1 Antiinfecciosos
K1 3303 Ingeniería y Tecnología Químicas
K1 2206.10 Polímeros
AB Polycaprolactone (PCL) and polycaprolactone-hydroxyapatite (PCL-HA) scaffolds were produced by foaming in supercritical carbon dioxide (scCO2) at 20 MPa, as well as in one-step foaming and impregnation process using carvacrol as an antibacterial agent with proven activity against Gram-positive and Gram-negative bacteria. The experimental design was developed to study the influence of temperature (40 °C and 50 °C), HA content (10 and 20 wt.%), and depressurization rate (one and two-step decompression) on the foams’ morphology, porosity, pore size distribution, and carvacrol impregnation yield. The characterization of the foams was carried out using scanning electron microscopy (SEM, SEM-FIB), Gay-Lussac density bottle measurements, and Fourier–transform infrared (FTIR) analyses. The obtained results demonstrate that processing PCL and PCL-HA scaffolds by means of scCO2 foaming enables preparing foams with porosity in the range of 65.55–74.39% and 61.98–67.13%, at 40 °C and 50 °C, respectively. The presence of carvacrol led to a lower porosity. At 40 °C and one-step decompression at a slow rate, the porosity of impregnated scaffolds was higher than at 50 °C and two- step fast decompression. However, a narrower pore size distribution was obtained at the last processing conditions. PCL scaffolds with HA resulted in higher carvacrol impregnation yields than neat PCL foams. The highest carvacrol loading (10.57%) was observed in the scaffold with 10 wt.% HA obtained at 50 °C.
PB MDPI
SN 2227-9717
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/62300
UL https://uvadoc.uva.es/handle/10324/62300
LA eng
NO Processes,  2022, Vol. 10, Nº. 3, 482
NO Producción Científica
DS UVaDOC
RD 24-nov-2024