RT info:eu-repo/semantics/article
T1 Influence of obesity on bone turnover markers and fracture risk in postmenopausal women
A1 López Gómez, Juan José
A1 Pérez Castrillon, José Luis
A1 García de Santos, Isabel María
A1 Pérez Alonso, María
A1 Izaola Jauregui, Olatz
A1 Primo Martín, David
A1 Luis Román, Daniel Antonio de
K1 Bones - Diseases
K1 Huesos - Enfermedades
K1 Bones - Metabolism - Disorders
K1 Huesos - Metabolismo, trastornos del
K1 Obesity
K1 Obesidad
K1 Osteoporosis
K1 Fractures
K1 Huesos - Fracturas
K1 Bone turnover markers
K1 Postmenopausal women
K1 Menopause
K1 Menopausia
K1 Nutrition
K1 32 Ciencias Médicas
K1 3206 Ciencias de la Nutrición
AB Background and aims: The relationship between obesity and bone metabolism is controversial. In recent decades, the protective role of obesity in the development of osteoporosis is questioned. The aims of this study are the following: to evaluate the differences in bone turnover markers between postmenopausal women with and without obesity and to compare the risk of fracture at five years between these groups. Methods: An observational longitudinal prospective cohort study of postmenopausal women with obesity (O) (body mass index (BMI) > 30 kg/m2) and non-obesity (NoO) (BMI < 30 kg/m2) is designed. 250 postmenopausal women are included in the study (NoO: 124 (49.6%) and O: 126 (50.4%)). It measures epidemiological variables, dietary variables (calcium intake, vitamin D intake, smoking, alcohol consumption, and physical activity), biochemicals (β-crosslap, type I procollagen amino-terminal peptide (P1NP), 25OH-vitamin D, and parathyroid hormone (PTH)), anthropometric variables, and fracture data five years after the start of the study. The mean age is 56.17 (3.91) years. Women with obesity showed lower levels of vitamin D (O: 17.27 (7.85) ng/mL, NoO: 24.51 (9.60) ng/mL; p < 0.01), and higher levels of PTH (O: 53.24 (38.44–65.96) pg/mL, NoO: 35.24 (25.36–42.40) pg/mL; p < 0.01). Regarding the bone formation marker (P1NP), it was found to be high in women without obesity, O: 45.46 (34.39–55.16) ng/mL, NoO: 56.74 (45.34–70.74) ng/mL; p < 0.01; the bone resorption marker (β-crosslap) was found to be high in women with obesity, being significant in those older than 59 years (O: 0.39 (0.14) ng/mL, NoO 0.24 (0.09) ng/mL; p < 0.05). No differences are observed in the risk of fracture at 5 years based on BMI (OR = 0.90 (95%CI 0.30–2.72); p = 0.85). Conclusions: Postmenopausal women with obesity showed lower levels of bone formation markers; older women with obesity showed higher markers of bone resorption.
PB MDPI
SN 2072-6643
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/62518
UL https://uvadoc.uva.es/handle/10324/62518
LA eng
NO Nutrients, 2022, Vol. 14, Nº. 8, 1617
NO Producción Científica
DS UVaDOC
RD 14-jul-2024