RT info:eu-repo/semantics/article
T1 Treatment of vitamin D deficiency with calcifediol: Efficacy and safety profile and predictability of efficacy
A1 Pérez Castrillon, José Luis
A1 Usategui Martín, Ricardo
A1 Pludowski, Pawel
K1 Clinical nutrition
K1 Cholecalciferol
K1 Vitamin D deficiency
K1 Vitamin D
K1 Vitamina D
K1 Safety profile
K1 Food - Biotechnology
K1 Food science
K1 Pharmacology
K1 Toxicity
K1 Toxicology
K1 Dietary supplements
K1 Suplementos nutritivos
K1 Calcifediol
K1 3206 Ciencias de la Nutrición
K1 3209 Farmacología
K1 3214 Toxicología
AB Calcifediol (25-OH-vitamin D3) is the prohormone of the vitamin D endocrine system. It is used to prevent and treat vitamin D deficiency. Calcifediol, as well as cholecalciferol (vitamin D3), is efficient and safe in the general population, although calcifediol has certain advantages over cholecalciferol, such as its rapid onset of action and greater potency. This review analyzed studies comparing the efficacy and safety of both calcifediol and cholecalciferol drugs in the short and long term (>6 months). Calcifediol was found to be more efficacious, with no increase in toxicity. We also assessed the predictability of both molecules. A 25OHD increase depends on the dose and frequency of calcifediol administration. In contrast, after cholecalciferol administration, 25OHD increase depends on more factors than dose and frequency of administration, also phenotypic aspects (such as obesity and malabsorption), and genotypic factors impacts in this increase.
PB MDPI
SN 2072-6643
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/62673
UL https://uvadoc.uva.es/handle/10324/62673
LA eng
NO Nutrients, 2022, Vol. 14, Nº. 9, 1943
NO Producción Científica
DS UVaDOC
RD 02-dic-2024