RT info:eu-repo/semantics/article
T1 Haplotypes in the GC, CYP2R1 and CYP24A1 genes and biomarkers of bone mineral metabolism in older adults
A1 Fernández Araque, Ana María
A1 Giaquinta Aranda, Andrea
A1 Moreno Sainz, Carmelo
A1 Marrón Martínez, María Cruz
A1 Velasco González, Verónica
A1 Sáinz Gil, María
A1 Martín Arias, Luis Hermenegildo
A1 Carretero Molinero, Silvia
A1 García Hidalgo, Miguel
A1 Verde Rello, Zoraida
K1 Older people - Care
K1 Personas de edad
K1 Geriatrics
K1 Genetic polymorphisms
K1 Genetics
K1 Vitamin D
K1 Vitamina D
K1 Albumin
K1 Albúmina
K1 Calcium
K1 Calcio
K1 Phosphorus
K1 Fósforo
K1 Parathyroid hormone
K1 Biomarkers
K1 3201.07 Geriatría
K1 2409 Genética
K1 2302.32 Vitaminas
AB Candidate gene studies have analyzed the effect of specific vitamin D pathway genes on vitamin D availability; however, it is not clear whether genetic variants also affect overall bone metabolism. This study evaluated the association between genetic polymorphisms in GC, CYP2R1 and CYP24A1 and serum levels of total 25(OH)D, iPTH and other mineral metabolism biomarkers (albumin, total calcium and phosphorus) in a sample of 273 older Spanish adults. We observed a significant difference between CYP2R1 rs10741657 codominant model and total 25(OH)D levels after adjusting them by gender (p = 0.024). In addition, the two SNPs in the GC gene (rs4588 and rs2282679) were identified significantly associated with iPTH and creatinine serum levels. In the case of phosphorus, we observed an association with GC SNPs in dominant model. We found a relationship between haplotype 2 and 25(OH)D levels, haplotype 4 and iPTH serum levels and haplotype 7 and phosphorus levels. In conclusion, genetic variants in CYP2R1 and GC could be predictive of 25(OH)D and iPTH serum levels, respectively, in older Caucasian adults. The current study confirmed the role of iPTH as one of the most sensitive biomarkers of vitamin D activity in vivo.
PB MDPI
SN 2072-6643
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/62863
UL https://uvadoc.uva.es/handle/10324/62863
LA eng
NO Nutrients, 2022, Vol. 14, Nº. 2, 259
NO Producción Científica
DS UVaDOC
RD 23-nov-2024