RT info:eu-repo/semantics/article
T1 Scleral changes induced by atropine in chicks as an experimental model of myopia
A1 Gallego Muñoz, Patricia
A1 Martínez García, María del Carmen
A1 Pérez Merino, Pablo
A1 Ibares Frías, Lucía
A1 Mayo Iscar, Agustín
A1 Merayo Lloves, Jesús
K1 Miopia - Tratamiento
AB Purpose: To determine the effects of intravitreal atropine on scleral growth in theform-deprived chick as an experimental model of myopia.Methods: Five groups of five chicks were studied from day 0–12 post-hatching.One group remained untreated (C), and four were form-deprived by monocularlight diffusers to induce myopia. Two groups (RL and A) wore diffusers for9 days, and the other two groups (D and D + A) wore diffusers throughout thestudy. Group D received no further treatment (myopia positive control). GroupsA and D + A received intravitreal injections of atropine for days 9–12. Measurementsof refractive error and axial length were performed on days 0, 9, and 12.Sclera changes were assessed in cartilaginous and fibrous layers by histologicalanalysis.Results: All form-deprived eyes had a myopic refractive error on day 9. All atropine-treated groups were hyperopic on day 12. The effect of atropine was mostevident in Group D + A in which diffusers were maintained throughout treatmentand changes in refractive error were statistically significant. The observedchanges in axial length were in line with the changes in refractive error. The scleralfibrous layer thickness increased, and the sceral cartilaginous layer underwent aslight thinning compared to Group D, the myopia positive control.Conclusions: If the signals that induce growth remain during atropine treatment,morphological changes in sclera are produced: the scleral fibrous layer thickened,and the sceral cartilaginous layer thinned. These changes resulted in refractiveerror recovery, and the ocular growth was stopped. The data suggested the atropinewas acting throughout the scleral fibrous layer.
PB The College of Optometrists
SN 0275-5408
YR 2012
FD 2012
LK http://uvadoc.uva.es/handle/10324/6288
UL http://uvadoc.uva.es/handle/10324/6288
LA eng
NO Ophtalmic and Physiological Optics, 2012, vol. 32, p. 478-484
NO Producción Científica
DS UVaDOC
RD 22-nov-2024