RT info:eu-repo/semantics/article
T1 Vitamin D receptor (VDR) gene polymorphisms modify the response to vitamin D supplementation: A systematic review and meta-analysis
A1 Usategui Martín, Ricardo
A1 Luis Román, Daniel Antonio de
A1 Fernández Gómez, José María Fidel
A1 Ruiz Mambrilla, Marta María
A1 Pérez Castrillon, José Luis
K1 Vitamin D receptor
K1 Vitamin D
K1 Vitamina D
K1 Genetic polymorphisms
K1 Genetics
K1 Human genetics
K1 Genética
K1 Supplementation
K1 Food science
K1 Nutrition
K1 Dietary supplements
K1 Suplementos nutritivos
K1 3206 Ciencias de la Nutrición
K1 3309 Tecnología de Los Alimentos
K1 3206.13 Vitaminas
AB The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic review and meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI, TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship between the response to vitamin D supplementation and the genotypic distribution of these polymorphisms. We included eight studies that enrolled 1038 subjects. The results showed no significant association with the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt) of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a better response to vitamin D supplementation (p = 0.02 and p < 0.001). In conclusion, the TaqI and FokI polymorphisms could play a role in the modulation of the response to vitamin D supplementation, as they are associated with a better response to supplementation.
PB MDPI
SN 2072-6643
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/63025
UL https://uvadoc.uva.es/handle/10324/63025
LA eng
NO Nutrients, 2022, Vol. 14, Nº. 2, 360
NO Producción Científica
DS UVaDOC
RD 24-nov-2024