RT info:eu-repo/semantics/article T1 Vitamin D receptor (VDR) gene polymorphisms modify the response to vitamin D supplementation: A systematic review and meta-analysis A1 Usategui Martín, Ricardo A1 Luis Román, Daniel Antonio de A1 Fernández Gómez, José María Fidel A1 Ruiz Mambrilla, Marta María A1 Pérez Castrillon, José Luis K1 Vitamin D receptor K1 Vitamin D K1 Vitamina D K1 Genetic polymorphisms K1 Genetics K1 Human genetics K1 Genética K1 Supplementation K1 Food science K1 Nutrition K1 Dietary supplements K1 Suplementos nutritivos K1 3206 Ciencias de la Nutrición K1 3309 Tecnología de Los Alimentos K1 3206.13 Vitaminas AB The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic review and meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI, TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship between the response to vitamin D supplementation and the genotypic distribution of these polymorphisms. We included eight studies that enrolled 1038 subjects. The results showed no significant association with the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt) of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a better response to vitamin D supplementation (p = 0.02 and p < 0.001). In conclusion, the TaqI and FokI polymorphisms could play a role in the modulation of the response to vitamin D supplementation, as they are associated with a better response to supplementation. PB MDPI SN 2072-6643 YR 2022 FD 2022 LK https://uvadoc.uva.es/handle/10324/63025 UL https://uvadoc.uva.es/handle/10324/63025 LA eng NO Nutrients, 2022, Vol. 14, Nº. 2, 360 NO Producción Científica DS UVaDOC RD 27-jun-2024