RT info:eu-repo/semantics/article
T1 Biological activities of ribosome-inactivating proteins
A1 Citores González, Lucía
A1 Ferreras Rodríguez, José Miguel
K1 Ribosome inactivating protein
K1 Proteins - Synthesis
K1 Proteínas - Síntesis
K1 Ribosomes - Structure
K1 Toxins
K1 Toxinas
K1 Biochemistry
K1 Toxicology
K1 2302.27 Proteínas
K1 2302 Bioquímica
K1 3214 Toxicología
AB After more than 50 years of research, studies on the structure and biological activities of ribosome-inactivating proteins (RIPs) continue to provide a field of great interest within the scientific community, both for the health risks they pose and their applications in medicine and biotechnology. This Special Issue of Toxins offers a sample of the main research topics when studying these proteins. RIPs are ribosomal RNA N-glycosylases (EC 3.2.2.22), mainly isolated from plants, some bacteria, and fungi, that specifically catalyze the hydrolysis of the second N-glycosidic bond of the GAGA tetraloop located in the sarcin-ricin loop (SRL) of the major ribosomal RNA. Because SRL is crucial for anchoring elongation factors in the ribosome, the removal of adenine causes the irreversible inactivation of ribosomes, leading to cell death. In addition, RIPs usually demonstrate other enzymatic activities, including,most relevantly, their adenine polynucleotide glycosylase (APG) activity on all nucleic acid types; that is, some RIPs can remove adenines from both ribosomal and non-ribosomal RNA and DNA [1]. [Texto extraído del artículo de Lucía Citores González].
PB MDPI
SN 2072-6651
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/63138
UL https://uvadoc.uva.es/handle/10324/63138
LA eng
NO Toxins, 2022, Vol. 15, Nº. 1, 35
NO Producción Científica
DS UVaDOC
RD 24-nov-2024