RT info:eu-repo/semantics/article
T1 Copper/zinc ratio in childhood and adolescence: A review
A1 Escobedo Monge, Marlene Fabiola
A1 Barrado Esteban, Enrique
A1 Parodi Román, Joaquín
A1 Escobedo Monge, María Antonieta
A1 Torres Hinojal, María Carmen
A1 Marugán de Miguelsanz, José Manuel
K1 Chronic diseases
K1 Enfermedades crónicas
K1 Zinc
K1 Copper
K1 Cobre
K1 Inflammation
K1 Inflamación
K1 Oxidative stress
K1 Estrés oxidativo
K1 Nutritional status
K1 Nutrition
K1 Childhood
K1 Niños
K1 Adolescence
K1 Adolescencia
K1 Pediatrics
K1 Biochemistry
K1 3206 Ciencias de la Nutrición
K1 32 Ciencias Médicas
K1 3201.10 Pediatría
K1 2302 Bioquímica
AB Both copper (Cu) and zinc (Zn) are crucial micronutrients for human growth and development. This literature review covered the last five years of available evidence on the Cu/Zn ratio in children and adolescents. We searched PubMed, Web of Science, Google Scholar, Cochrane Library, and Science Direct for publications between 2017 and 2022, especially in English, although publications in other languages with abstracts in English were included. The main terms used were “copper”, “zinc”, “copper-zinc”, and “zinc-copper” ratios. Cu and Zn determinations made in blood, plasma, or serum were included. This review comprises several cross-sectional and case–control studies with substantial results. The bibliographic search generated a compilation of 19 articles, in which 63.2% of the studies mostly reported a significantly higher Cu/Zn ratio, and 57.9% of them informed significantly lower levels of Zn. We conclude that children and adolescents with acute and chronic conditions are at greater risk of developing elevated Cu/Zn ratios, related to altered nutritional, infectious, and inflammatory status.
PB MDPI
SN 2218-1989
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/63190
UL https://uvadoc.uva.es/handle/10324/63190
LA eng
NO Metabolites, 2023, Vol. 13, Nº. 1, 82
NO Producción Científica
DS UVaDOC
RD 24-nov-2024