RT info:eu-repo/semantics/article
T1 Is curcumine useful in the treatment and prevention of the tendinopathy and myotendinous junction injury? A scoping review
A1 Córdova Martínez, Alfredo
A1 Drobnic, Franchek
A1 Noriega González, David César
A1 Caballero García, Alberto
A1 Roche Collado, Enrique
A1 Álvarez Mon, Melchor
K1 Cytokines
K1 Citoquinas
K1 Curcumin
K1 Curcumina
K1 Alimentos - Aditivos
K1 Exercise
K1 Ejercicio físico
K1 Inflammation
K1 Inflamación
K1 Nutrition
K1 Tendinopathies
K1 Tendons - Wounds and injuries - Treatment
K1 Tendones - Lesiones y heridas
K1 3206 Ciencias de la Nutrición
K1 2411.06 Fisiología del Ejercicio
K1 32 Ciencias Médicas
AB Physical activity in general and sports in particular, is a mechanism that produces stress and generates great force in the tendon and in the muscle-tendon unit, which increases the risk of injury (tendinopathies). Eccentric and repetitive contraction of the muscle precipitates persistent microtraumatism in the tendon unit. In the development of tendinopathies, the cellular process includes inflammation, apoptosis, vascular, and neuronal changes. Currently, treatments with oral supplements are frequently used. Curcumin seems to preserve, and even repair, damaged tendons. In this systematic review, we focus more especially on the benefits of curcumin. The biological actions of curcumin are diverse, but act around three systems: (a) inflammatory, (b) nuclear factor B (NF-κB) related apoptosis pathways, and (c) oxidative stress systems. A bibliographic search is conducted under the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) as a basis for reporting reliable systematic reviews to perform a Scoping review. After analysing the manuscripts, we can conclude that curcumin is a product that demonstrates a significant biological antialgic, anti-inflammatory, and antioxidant power. Therefore, supplementation has a positive effect on the inflammatory and regenerative response in tendinopathies. In addition, curcumin decreases and modulates the cell infiltration, activation, and maturation of leukocytes, as well as the production of pro-inflammatory mediators at the site of inflammation.
PB MDPI
SN 2072-6643
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/63251
UL https://uvadoc.uva.es/handle/10324/63251
LA eng
NO Nutrients, 2023, Vol. 15, Nº. 2, 384
NO Producción Científica
DS UVaDOC
RD 11-jul-2024